Literature summary for 1.11.1.8 extracted from

Schmutzler, C.; Bacinski, A.; Gotthardt, I.; Huhne, K.; Ambrugger, P.; Klammer, H.; Schlecht, C.; Hoang-Vu, C.; Grueters, A.; Wuttke, W.; Jarry, H.; Koehrle, J.
The ultraviolet filter benzophenone 2 interferes with the thyroid hormone axis in rats and is a potent in vitro inhibitor of human recombinant thyroid peroxidase (2007), Endocrinology, 148, 2835-2844.

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Inhibitors

Inhibitors	Comment	Organism	Structure
benzophenone 2	inactivation is prevented by iodideone of the most potent inhibitors of TPO	Homo sapiens
bisphenol A	-	Homo sapiens
F21388	-	Homo sapiens
H2O2	inactivation is prevented by iodide	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	recombinant	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
additional information	recombinant TPO stably transfected into the human follicular thyroid carcinoma cell line FTC-238	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
iodide + H2O2	-	Homo sapiens	iodine + H2O	-	?

Synonyms

Synonyms	Comment	Organism
hrTPO	-	Homo sapiens

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Release 2023.1 (January 2023)