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Literature summary for 1.11.1.8 extracted from

  • Ferreira, A.C.; Neto, J.C.; da Silva, A.C.; Kuster, R.M.; Carvalho, D.P.
    Inhibition of thyroid peroxidase by Myrcia uniflora flavonoids (2006), Chem. Res. Toxicol., 19, 351-355.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
mearnsitrin IC50: 0.00197 mM. Flavonoid from aqueous partition of Myrcia uniflora. Indiscriminated consumption of Myrcia uniflora pharmaceutical products allied to the nutritional deficiency of iodine might contribute to the development of hypothyroidism and goiter Homo sapiens
Myricitrin IC50: 0.00188 mM. Flavonoid from aqueous partition of Myrcia uniflora. Indiscriminated consumption of Myrcia uniflora pharmaceutical products allied to the nutritional deficiency of iodine might contribute to the development of hypothyroidism and goiter Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
thyroid gland toxic diffuse goiter tissue samples obtained during thyroidectomies Homo sapiens
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00188
-
IC50: 0.00188 mM. Flavonoid from aqueous partition of Myrcia uniflora. Indiscriminated consumption of Myrcia uniflora pharmaceutical products allied to the nutritional deficiency of iodine might contribute to the development of hypothyroidism and goiter Homo sapiens Myricitrin
0.00197
-
IC50: 0.00197 mM. Flavonoid from aqueous partition of Myrcia uniflora. Indiscriminated consumption of Myrcia uniflora pharmaceutical products allied to the nutritional deficiency of iodine might contribute to the development of hypothyroidism and goiter Homo sapiens mearnsitrin