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Literature summary for 1.11.1.7 extracted from
- Lactoperoxidase catalyzes in vitro activation of acrylonitrile to cyanide (2009), Toxicol. Lett., 191, 347-352.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| D-penicillamine | D-penicillamine achieves 128.3% of the rate of cyanide production of the control in the LPO/H2O2/acetonitrile system | Bos taurus |  |
| glutathione | glutathione achieves 138.8% of the rate of cyanide production of the control in the LPO/H2O2/acetonitrile system | Bos taurus | |
| L-cysteine | L-cysteine is associated with the highest boost in the rate of cyanide formation in the LPO/H2O2/acetonitrile system, achieving 156.7% of the rate of cyanide production of the control | Bos taurus | |
| N-acetylcysteine | N-acetylcysteine achieves 123.4% of the rate of cyanide production of the control in the LPO/H2O2/acetonitrile system | Bos taurus | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| indomethacin | the presence of indomethacin in the LPO/H2O2/acetonitrile system leads to a modest, yet significant decline in the rate of cyanide formation of only 84.1% of the control | Bos taurus | |
| quercetin | incubation of the LPO/H2O2/acetonitrile system with 0.1 mM quercetin is associated with the highest rate of inhibition amounting to 40.2% of the control | Bos taurus | |
| resorcinol | incubation of the LPO/H2O2/acetonitrile system with resorcinol is associated with amoderate decline in the rate of cyanide production which is 64.8% of the control | Bos taurus | |
| Sodium azide | incubation of the LPO/H2O2/acetonitrile system with sodium azide is associated with amoderate decline in the rate of cyanide production which is 61.6% of the control | Bos taurus | |
| trolox C | incubation of the LPO/H2O2/acetonitrile system with 0.1 mM trolox C is associated with the highest rate of inhibition amounting to 47.8% of the control | Bos taurus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| milk | - |
Bos taurus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
the maximal rate of cyanide generation observed at pH 5.0 and 37°C is 139.7 pmol/ml/min on average | Bos taurus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acrylonitrile + H2O2 | - |
Bos taurus | cyanide + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| lactoperoxidase | - |
Bos taurus |
| LPO | - |
Bos taurus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
the highest rate of cyanide formation is recorded at a temperature of 37°C | Bos taurus |
Temperature Range [°C]
| Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 15 | 60 | LPO enzyme activity is retained between 15°C and 60°C | Bos taurus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 5 | - |
the highest rate of cyanide formation is recorded at pH 5.0 | Bos taurus |
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Release 2023.1 (January 2023)
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