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Literature summary for 1.11.1.7 extracted from

  • Kapralov, A.; Vlasova, I.I.; Feng, W.; Maeda, A.; Walson, K.; Tyurin, V.A.; Huang, Z.; Aneja, R.K.; Carcillo, J.; Bayir, H.; Kagan, V.E.
    Peroxidase activity of hemoglobin-haptoglobin complexes: Covalent aggregation and oxidative stress in plasma and macrophages (2009), J. Biol. Chem., 284, 30395-30407.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.11.1.7

Inhibitors

Inhibitors Comment Organism Structure
Haptoglobin mixed type of inhibition, haptoglobin binds with hemoglobin and weakens hemoglobin peroxidase activity Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens under conditions of severe inflammation and oxidative stress, peroxidase activity of hemoglobin-haptoglobin covalent aggregates may cause macrophage dysfunction and microvascular vasoconstriction ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Amplex Red + H2O2
-
 Homo sapiens ?
-
 ?
L-ascorbate + H2O2
-
 Homo sapiens dehydroascorbate + H2O
-
 ?
additional information under conditions of severe inflammation and oxidative stress, peroxidase activity of hemoglobin-haptoglobin covalent aggregates may cause macrophage dysfunction and microvascular vasoconstriction Homo sapiens ?
-
 ?
West Pico + H2O2
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Hb peroxidase
-
 Homo sapiens
hemoglobin peroxidase as a hemoprotein, hemoglobin can, in the presence of H2O2, act as a peroxidase Homo sapiens