Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of disruption knockout mutant DELTAZmcytC, phenotype, overview | Zymomonas mobilis |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Zymomonas mobilis | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Iron | heme enzyme | Zymomonas mobilis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 ferrocytochrome c + H2O2 | Zymomonas mobilis | - |
2 ferricytochrome c + 2 H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Zymomonas mobilis | Q5NNF0 | gene ZmcytC | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 ferrocytochrome c + H2O2 | - |
Zymomonas mobilis | 2 ferricytochrome c + 2 H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CCP | - |
Zymomonas mobilis |
CytC | - |
Zymomonas mobilis |
cytochrome c peroxidase | - |
Zymomonas mobilis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
heme | the enzyme bears three heme c-binding motifs | Zymomonas mobilis |
General Information | Comment | Organism |
---|---|---|
malfunction | an enzyme knockout mutant DELTAZmcytC exhibits filamentous shapes and reduction in growth under a shaking condition at a high temperature compared to the parental strain and became hypersensitive to exogenous H2O2. Under the same condition, the mutation causes increased expression of genes for three other antioxidant enzymes. Peroxidase activity almost abolished in mutant DELTA ZmcytC. The enzyme knockout mutant strain shows activity with ubiquinol-1 as a substrate but not with reduced horse heart cytochrome c, and it shows antimycin A-sensitive NADH oxidase activity | Zymomonas mobilis |
physiological function | involvement of ZmCytC in the aerobic respiratory chain via the cytochrome bc1 complex in addition to the previously proposed direct interaction with ubiquinol and its contribution to protection against oxidative stress | Zymomonas mobilis |