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Literature summary for 1.11.1.23 extracted from
- Structure and reactivity of hydroxypropylphosphonic acid epoxidase in fosfomycin biosynthesis by a cation- and flavin-dependent mechanism (2005), Proc. Natl. Acad. Sci. USA, 102, 14221-14226.
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| crystal structures of holoenzyme and the complex with fosfomycin are determined and reveal a two-domain combination and Zn2+ in the active site | Streptomyces wedmorensis |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Fe2+ | the recombinant enzyme is active, when reconstituted with Zn2+ or Fe2+ | Streptomyces wedmorensis |  |
| Zn2+ | the recombinant enzyme is active, when reconstituted with Zn2+ or Fe2+ | Streptomyces wedmorensis | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Streptomyces wedmorensis | Q56185 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Streptomyces wedmorensis |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| (S)-2-hydroxypropylphosphonate + H2O2 = (1R,2S)-1,2-epoxypropylphosphonate + 2 H2O | a straightforward epoxidase mechanism is proposed that depends on the Lewis acid properties of divalent cations and the redox properties of FMN | Streptomyces wedmorensis |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| HppE | - |
Streptomyces wedmorensis |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FMN | a straightforward epoxidase mechanism is proposed that depends on the Lewis acid properties of divalent cations and the redox properties of FMN | Streptomyces wedmorensis | |
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