Organism | UniProt | Comment | Textmining |
---|---|---|---|
Synechocystis sp. | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme isoforms GPX-1 and GPX-2 do not utilize reduced glutathione and unsaturated fatty acid hydroperoxides or alkyl hydroperoxides | Synechocystis sp. | ? | - |
? | |
tert-butyl hydroperoxide + NADPH + H+ | - |
Synechocystis sp. | ? + NADP+ + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
glutathione peroxidase-like protein | - |
Synechocystis sp. |
Gpx-1 | isoform | Synechocystis sp. |
GPx-2 | isoform | Synechocystis sp. |
slr1171 | - |
Synechocystis sp. |
slr1992 | - |
Synechocystis sp. |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Synechocystis sp. |
Organism | Comment | Expression |
---|---|---|
Synechocystis sp. | no significant change in the protein level of GPX-2 is observed upon treatment with tert-butyl hydroperoxide | additional information |
Synechocystis sp. | the steady-state transcript level of gpx-1 gradually increases under oxidative stress conditions imposed by high light intensity (0.35 mE m.2 s-1), high salinity (200 mM NaCl), or application of methyl viologen (0.001 mM) or tert-butyl hydroperoxide (0.001 mM) in the wild type and GPX-2 knock-out mutant cells. The protein level of GPX-2 increases approximately 3fold and 1.6fold at 3 h with the methyl viologen and NaCl treatments, respectively. Under high light conditions, the protein level of GPX-2 increases approximately 1.2fold | up |
General Information | Comment | Organism |
---|---|---|
physiological function | isoforms GPX-1 and GPX-2 are essential for the removal of lipid hydroperoxides under normal and stress conditions, leading to the protection of membrane integrity | Synechocystis sp. |