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Literature summary for 1.11.1.18 extracted from

  • Wischang, D.; Hartung, J.
    Bromination of phenols in bromoperoxidase-catalyzed oxidations (2012), Tetrahedron, 68, 9456-9463.
No PubMed abstract available

Metals/Ions

Metals/Ions Comment Organism Structure
vanadate in the solid state structure, every protein monomer binds one vanadate to the tele imidazole nitrogen of residue His486. In solutions of sodium orthovanadate, isoform apobromoperoxidase II recovers bromoperoxidase activity by one order of magnitude faster than apobromoperoxidase I Ascophyllum nodosum

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
67400
-
2 * 67400, calculated, 2 * 64200-65000, MALDI-TOF Ascophyllum nodosum
127700 130000 MALDI-TOF Ascophyllum nodosum
136000
-
gel filtration Ascophyllum nodosum

Organism

Organism UniProt Comment Textmining
Ascophyllum nodosum P81701 isoform VBrPO(AnI)
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Br- + H2O2 + 2-methoxyphenol
-
Ascophyllum nodosum 2-bromo-6-methoxyphenol + 4-bromo-6-methoxyphenol + H2O 56% of product, in a 21/79 mixture of o-/p-regioisomers, plus 10% 2,4-dibromo-6-methoxyphenol ?
Br- + H2O2 + 2-methylphenol
-
Ascophyllum nodosum 2-bromo-6-methylphenol + 4-bromo-6-methylphenol + H2O 68% of product, in a 16/84 mixture of o-/p-regioisomers, plus 4% 2,4-dibromophenol ?
Br- + H2O2 + 2-t-butylphenol
-
Ascophyllum nodosum 2-bromo-6-t-butylphenol + 4-bromo-6-t-butylphenol + H2O 42% of product, in a 36/64 mixture of o-/p-regioisomers, plus 2% 2,4-dibromo-6-t-butylphenol ?
Br- + H2O2 + phenol
-
Ascophyllum nodosum 2-bromophenol + 4-bromophenol + H2O 69% of product, in a 91/9 mixture of o-/p-regioisomers, plus 3% 2,4-dibromo-6-methylphenol and some 2,4,6-tribromophenol ?
additional information enzyme uses hydrogen peroxide and bromide yielding molecular bromine as reagent for electrophilic hydrocarbon bromination Ascophyllum nodosum ?
-
?

Subunits

Subunits Comment Organism
dimer 2 * 67400, calculated, 2 * 64200-65000, MALDI-TOF Ascophyllum nodosum

Synonyms

Synonyms Comment Organism
apobromoperoxidase I
-
Ascophyllum nodosum
VBrPO(AnI)
-
Ascophyllum nodosum