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Literature summary for 1.11.1.18 extracted from

  • Wischang, D.; Hartung, J.; Hahn, T.; Ulber, R.; Stumpf, T.; Fecher-Trost, C.
    Vanadate(v)-dependent bromoperoxidase immobilized on magnetic beads as reusable catalyst for oxidative bromination (2011), Green Chem., 13, 102-108.
No PubMed abstract available
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Application

Application Comment Organism
synthesis immobilization of enzyme on magnetic micrometre-sized particles in quantitative yields, with up to 40% retention of initial bromoperoxidase activity. The immobilized enzyme is stable with a half-life time of about 160 days. It serves as reusable catalyst for bromide oxidation with H2O2 in up to 14 consecutive experiments. Immobilized enzyme is used for methyl pyrrole-2-carboxylate conversion into derivatives of naturally occurring compounds e.g. from Agelas oroides with product selectivity of up to 75% Ascophyllum nodosum

Organism

Organism UniProt Comment Textmining
Ascophyllum nodosum P81701
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Br- + H2O2 + methyl pyrrole-2-carboxylate
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 Ascophyllum nodosum methyl 4-bromo-1H-pyrrole-2-carboxylate + methyl 5-bromo-1H-pyrrole-2-carboxylate + H2O quantitative conversion within 24 h, 94% of product in 93/7 ratio of 4-/5-substituted regioisomers ?