Literature summary for 1.11.1.12 extracted from

Baek, I.J.; Yon, J.M.; Lee, S.R.; Jin, Y.; Kim, M.R.; Ahn, B.; Hong, J.T.; Choo, Y.K.; Lee, B.J.; Yun, Y.W.; Nam, S.Y.
Effects of endocrine disrupting chemicals on expression of phospholipid hydroperoxide glutathione peroxidase mRNA in rat testes (2007), J. Vet. Sci., 8, 213-218.

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Application

Application	Comment	Organism
medicine	PHGPx is useful as a biomarker to screen for detrimental effects of exogenous endocrine disrupting chemicals in testes	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
testis	treatment with testosterone slightly decreases PHGPx mRNA levels in testes by the reverse transcription-polymerase chain reaction. Anti-androgenic compounds (flutamide, ketoconazole, and diethylhexyl phthalate) and estrogenic compounds (nonylphenol, octylphenol, and diethylstilbestrol) significantly upregulate PHGPx mRNA in the testes. Endocrine disrupting chemicals might have a detrimental effect on spermatogenesis via abnormal enhancement of PHGPx expression in testes	Rattus norvegicus	-

Synonyms

Synonyms	Comment	Organism
PHGPX	-	Rattus norvegicus

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Release 2023.1 (January 2023)