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Literature summary for 1.11.1.12 extracted from

  • Januel, C.; El Hentati, F.; Carreras, M.; Arthur, J.R.; Calzada, C.; Lagarde, M.; Vericel, E.
    Phospholipid-hydroperoxide glutathione peroxidase (GPx-4) localization in resting platelets, and compartmental change during platelet activation (2006), Biochim. Biophys. Acta, 1761, 1228-1234.
    View publication on PubMed
Search for more literature for 1.11.1.12

Inhibitors

Inhibitors Comment Organism Structure
iodoacetate 2 mM, complete inhibition Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-
membrane
-
 Homo sapiens 16020
-
mitochondrion
-
 Homo sapiens 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
20000
-
 1 * 20000, non-mitochondrial S-form of the enzyme Homo sapiens
23000
-
 1 * 23000, mitochondrial L-form of the enzyme Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
blood platelet resting blood platelet Homo sapiens
-
erythrocyte
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0038
-
 crude platelet homogenate Homo sapiens
0.0048
-
 cytosolic fraction Homo sapiens
0.006
-
 mitochondrial fraction Homo sapiens
0.0096
-
 membrane fraction Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glutathione + L-alpha-phosphatidylcholine hydroperoxide
-
 Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
monomer 1 * 20000, non-mitochondrial S-form of the enzyme Homo sapiens
monomer 1 * 23000, mitochondrial L-form of the enzyme Homo sapiens

Synonyms

Synonyms Comment Organism
GPx-4
-
 Homo sapiens