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Literature summary for 1.10.5.1 extracted from

  • Janda, E.; Martino, C.; Riillo, C.; Parafati, M.; Lascala, A.; Mollace, V.; Boutin, J.A.
    Apigenin and luteolin regulate autophagy by targeting NRH-quinone oxidoreductase 2 in liver cells (2021), Antioxidants (Basel), 10, 776 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.10.5.1

Inhibitors

Inhibitors Comment Organism Structure
apigenin
-
 Homo sapiens
diosmetin
-
 Homo sapiens
eridictylol
-
 Homo sapiens
hesperetin
-
 Homo sapiens
luteolin
-
 Homo sapiens
naringenin
-
 Homo sapiens
quercetin
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P16083
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
 Homo sapiens
-
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
menadione + 1-benzyl-1,4-dihydronicotinamide
-
 Homo sapiens ?
-
 ?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00015
-
 pH 8.5, 25°C Homo sapiens luteolin
0.00028
-
 pH 8.5, 25°C Homo sapiens apigenin
0.00053
-
 pH 8.5, 25°C Homo sapiens quercetin
0.0074
-
 pH 8.5, 25°C Homo sapiens diosmetin
0.049
-
 pH 8.5, 25°C Homo sapiens naringenin
0.07
-
 pH 8.5, 25°C Homo sapiens hesperetin
0.081
-
 pH 8.5, 25°C Homo sapiens eridictylol

General Information

General Information Comment Organism
physiological function silencing of NQO2 strongly reduces flavone-induced autophagic flux, although it increases basal LC3-II levels in HepG2 cells. Flavones apigenin and luteolin induce AMP kinase (AMPK) activation, while its reduction by AMPK beta (PRKAB1) silencing inhibits flavone-induced autophagy. The depletion of NQO2 levels by siRNA increases the basal AMPK phosphorylation but abrogates its further increase by apigenin Homo sapiens