Literature summary for 1.10.5.1 extracted from

Zhang, J.; Zhou, Y.; Li, N.; Liu, W.; Liang, J.; Sun, Y.; Zhang, W.; Fang, R.; Huang, S.; Sun, Z.; Wang, Y.; He, Q.
Curcumol overcomes TRAIL resistance of non-small cell lung cancer by targeting NRH quinone oxidoreductase 2 (NQO2) (2020), Adv. Sci. (Weinh.), 7, 2002306 .

Search for more literature for 1.10.5.1

Application

Application	Comment	Organism
medicine	NQO2 protein level is significantly higher in non-small cell lung cancer tissues as compared with their normal tissues. NQO2 score at clinical stages III and IV is higher than stage I, and there exists a significant correlation between tumor NQO2 expression level and the pathologic T stage	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	mutation of residue Phe178 completely abolishes the function of NQO2 and augments the TRAIL sensitization	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
curcumol	curcumol directly targets NQO2 to cause reactive oxygen species generation, which triggers endoplasmic reticulum stress-C/EBP homologous protein death receptor signaling, sensitizing non-small cell lung cancer cells to tumor-necrosis-factor-related apoptosis-inducing ligand (TRAIl) induced apoptosis. Presence of curcumol increases thermal stability of NQO2. Residue Phe178 in NQO2 is a critical site for curcumol binding	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
A-549 cell	-	Homo sapiens	-
NCI-H1299 cell	-	Homo sapiens	-
NCI-H1975 cell	-	Homo sapiens	-
NCI-H358 cell	-	Homo sapiens	-
NCI-H460 cell	-	Homo sapiens	-

General Information

General Information	Comment	Organism
physiological function	in NQ2 knockout cells, cell growth is slower. In a mouse model with xenografts formed by NQO2 knockout cells, the NQO2 knockout group exhibited significant smaller tumor volume and tumor weight than the control. Deletion of NQO2 suppresses cancer proliferation in vivo	Homo sapiens

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Release 2023.1 (January 2023)