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Literature summary for 1.10.5.1 extracted from
- Unexpected genetic and structural relationships of a long-forgotten flavoenzyme to NAD(P)H:quinone reductase (DT-diaphorase) (1997), Proc. Natl. Acad. Sci. USA, 94, 1669-1674.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| overexpression in Escherichia coli | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| benzo[a]pyrene | 0.0001 mM, 75% inhibition | Homo sapiens |  |
| dicoumarol | 0.01 mM, marginal inhibition | Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 24600 | - |
x * 24600, SDS-PAGE | Homo sapiens |
| 40000 | - |
gel filtration | Bos taurus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Bos taurus | - |
| liver | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 242 | - |
- |
Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| N-methyldihydronicotinamide + menadione | - |
Homo sapiens | ? | - |
? | |
| reduced N-methyldihydronicotinamide + menadione | - |
Bos taurus | ? + menadiol | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 24600, SDS-PAGE | Homo sapiens |
| dimer | - |
Bos taurus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| bQR2 | - |
Bos taurus |
| QR2 | - |
Homo sapiens |
| quinone reductase type 2 | - |
Homo sapiens |
| quinone reductase type 2 | - |
Bos taurus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | mediates hydride transfer, very tightly bound to the enzyme. Activity of the purified enzyme is not further increased by added FAD | Homo sapiens | |
| FAD | very tightly bound to the enzyme. Activity of the purified enzyme is not further increased by added FAD | Bos taurus | |
| additional information | completely inert to NADPH, NADH and NMNH | Homo sapiens |
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Release 2023.1 (January 2023)
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