Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.10.5.1 extracted from

  • Liao, S.; Dulaney, J.T.; Williams-Ashman, H-.G.
    Purification and properties of a flavoprotein catalyzing the oxidation of reduced ribosyl nicotinamide (1962), J. Biol. Chem., 237, 2981-2987.
    View publication on PubMed
Search for more literature for 1.10.5.1

Inhibitors

Inhibitors Comment Organism Structure
1,4-dimethylphenanthrene 0.00001 mM, 15% inhibition of the reaction with N1-(n-propyl)-nicotinamide Bos taurus
12-methylbenz[a]anthracene 0.00001 mM, 51% inhibition of the reaction with N1-(n-propyl)-nicotinamide Bos taurus
7,12-dimethylbenz[a]anthracene 0.00001 mM, 51% inhibition of the reaction with N1-(n-propyl)-nicotinamide Bos taurus
7-methylbenz[a]anthracene 0.00001 mM, 66% inhibition of the reaction with N1-(n-propyl)-nicotinamide Bos taurus
9,10-dimethylanthracene 0.00001 mM, 25% inhibition of the reaction with N1-(n-propyl)-nicotinamide Bos taurus
9-methylanthracene 0.00001 mM, 26% inhibition of the reaction with N1-(n-propyl)-nicotinamide Bos taurus
benz[a]anthracene 0.00001 mM, 40% inhibition of the reaction with N1-(n-propyl)-nicotinamide Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0016
-
 menadione pH 7.6, with reduced N1-(n-propyl)-nicotinamide as acceptor Bos taurus
0.023
-
 reduced N1-(n-propyl)-nicotinamide pH 7.6 Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-
erythrocyte
-
 Rattus norvegicus
-
heart
-
 Rattus norvegicus
-
kidney
-
 Rattus norvegicus
-
kidney
-
 Bos taurus
-
liver
-
 Rattus norvegicus
-
additional information no activity in blood plasma Rattus norvegicus
-
prostate gland ventral lobe
-
 Rattus norvegicus
-
seminal vesicle
-
 Rattus norvegicus
-
skeletal muscle
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dihydronicotinamide riboside + menadione
-
 Bos taurus ribosyl nicotinamide + menadiol
-
 ?
additional information no activity with NADH, NADPH, NMNH, reduced 3-acetylpyridine adenine dinucleotide, xanthine or hypoxanthine. No activity with 1,4-benzoquinone and potassium ferricyanide Bos taurus ?
-
 ?
reduced N1-(benzyl)-nicotinamide + menadione
-
 Bos taurus N1-(benzyl)-nicotinamide + menadiol
-
 ?
reduced N1-(methyl)-nicotinamide + menadione
-
 Bos taurus N1-(methyl)-nicotinamide + reduced menadiol
-
 ?
reduced N1-(n-propyl)-nicotinamide + menadione
-
 Bos taurus N1-(n-propyl)-nicotinamide + menadiol
-
 ?

Synonyms

Synonyms Comment Organism
N-ribosyldihydronicotinamide dehydrogenase (quinone)
-
 Bos taurus
NQO2
-
 Rattus norvegicus
NQO2
-
 Bos taurus
NRH-oxidizing enzyme
-
 Bos taurus
NRH:quinone oxidoreductase 2
-
 Rattus norvegicus
NRH:quinone oxidoreductase 2
-
 Bos taurus
QR2
-
 Bos taurus
quinone reductase 2
-
 Bos taurus

Cofactor

Cofactor Comment Organism Structure
FAD the enzyme contains FAD as the sole bound flavin. The prosthetic group can be removed by treatment with acid in ammonium sulfate, and the resolved enzyme may be reactivated by FAD or by higher concentrations FMN Bos taurus
FMN the enzyme contains FAD as the sole bound flavin. The prosthetic group can be removed by treatment with acid in ammonium sulfate, and the resolved enzyme may be reactivated by FAD or by higher concentrations FMN Bos taurus