Any feedback?
Literature summary for 1.10.5.1 extracted from
- Quinone reductase 2 substrate specificity and inhibitgion pharmacology (2005), Chem. Biol. Interact., 151, 213-228.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 5-hydroxyflavone | IC50: 340 nM | Homo sapiens |  |
| apigenin | IC50: 430 nM | Homo sapiens | |
| chrysin-dimethylether | IC50: 0.0013 mM | Homo sapiens | |
| chrysoeriol | IC50: 300 nM | Homo sapiens | |
| genistein | - |
Homo sapiens | |
| isorhamnetin | IC50: 860 nM | Homo sapiens | |
| kaempferol | IC50: 380 nM | Homo sapiens | |
| luteolin | IC50: 780 nM | Homo sapiens | |
| quercetin | IC50: 0.0014 mM | Homo sapiens | |
| quercetin-3-O-beta-glucopyranosyl | IC50: 0.0015 mM | Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0067 | - |
menadione | - |
Homo sapiens | |
| 0.02 | - |
N-benzyldihydronicotinamide | - |
Homo sapiens | |
| 2 | - |
tetrahydrofolate | - |
Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Homo sapiens | 5829 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
expressed in CHO cells | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| N-benzyldihydronicotinamide + coenzyme Q0 | - |
Homo sapiens | ? | - |
? | |
| N-benzyldihydronicotinamide + menadione | - |
Homo sapiens | ? | - |
? | |
| N-benzylnicotinamide + menadiol | - |
Homo sapiens | ? | - |
? | |
| N-ribosylnicotinamide + menadiol | N-ribosylnicotinamide is a poor substrate | Homo sapiens | ? | - |
? | |
| tetrahydrofolate + menadiol | - |
Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| quinone reductase 2 | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | - |
Homo sapiens | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0003 | - |
IC50: 300 nM | Homo sapiens | chrysoeriol | |
| 0.00034 | - |
IC50: 340 nM | Homo sapiens | 5-hydroxyflavone | |
| 0.00038 | - |
IC50: 380 nM | Homo sapiens | kaempferol | |
| 0.00043 | - |
IC50: 430 nM | Homo sapiens | apigenin | |
| 0.00078 | - |
IC50: 780 nM | Homo sapiens | luteolin | |
| 0.00086 | - |
IC50: 860 nM | Homo sapiens | isorhamnetin | |
| 0.0013 | - |
IC50: 0.0013 mM | Homo sapiens | chrysin-dimethylether | |
| 0.0014 | - |
IC50: 0.0014 mM | Homo sapiens | quercetin | |
| 0.0015 | - |
IC50: 0.0015 mM | Homo sapiens | quercetin-3-O-beta-glucopyranosyl | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
