Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.10.3.11 extracted from

  • Gao, Y.; Meyer, B.; Sokolova, L.; Zwicker, K.; Karas, M.; Brutschy, B.; Peng, G.; Michel, H.
    Heme-copper terminal oxidase using both cytochrome c and ubiquinol as electron donors (2012), Proc. Natl. Acad. Sci. USA, 109, 3275-3280.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.10.3.11

Inhibitors

Inhibitors Comment Organism Structure
cyanide
-
 Aquifex aeolicus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Aquifex aeolicus 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Cu2+ heme-copper terminal oxidase Aquifex aeolicus
Fe2+ heme-copper terminal oxidase Aquifex aeolicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
5200
-
 1 * 63900, subunit I CoxA2, + 1 * 16800, subunit II CoxB2, + 1 * 5200, subunit IIa, about, mass spectrometry Aquifex aeolicus
16800
-
 1 * 63900, subunit I CoxA2, + 1 * 16800, subunit II CoxB2, + 1 * 5200, subunit IIa, about, mass spectrometry Aquifex aeolicus
63900
-
 1 * 63900, subunit I CoxA2, + 1 * 16800, subunit II CoxB2, + 1 * 5200, subunit IIa, about, mass spectrometry Aquifex aeolicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 ubiquinol + O2 Aquifex aeolicus
-
 2 ubiquinone + 2 H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Aquifex aeolicus G5DGC8 subunit II, Coxb2
-

Purification (Commentary)

Purification (Comment) Organism
native enzyme from membranes by anion exchange chromatography and gel filtration Aquifex aeolicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 ubiquinol + O2
-
 Aquifex aeolicus 2 ubiquinone + 2 H2O
-
 ?
additional information the enzyme is able to oxidize both reduced cytochrome c and ubiquinol Aquifex aeolicus ?
-
 ?

Subunits

Subunits Comment Organism
More subunit composition and structures, overview. No cytochrome bc1 complex subunit Aquifex aeolicus
trimer 1 * 63900, subunit I CoxA2, + 1 * 16800, subunit II CoxB2, + 1 * 5200, subunit IIa, about, mass spectrometry Aquifex aeolicus

Synonyms

Synonyms Comment Organism
Cox2
-
 Aquifex aeolicus
cytochrome ba3 oxidase
-
 Aquifex aeolicus
heme-copper terminal oxidase
-
 Aquifex aeolicus

Cofactor

Cofactor Comment Organism Structure
heme b
-
 Aquifex aeolicus
heme c
-
 Aquifex aeolicus
additional information pyridine hemochromes of extracted hemes Aquifex aeolicus

pI Value

Organism Comment pI Value Maximum pI Value
Aquifex aeolicus band 1, isoelectric focusing
-
 6.4
Aquifex aeolicus band 2, isoelectric focusing
-
 7

General Information

General Information Comment Organism
evolution the cytochrome ba3 oxidase belongs to the family B of the heme-copper containing terminal oxidases, heme-copper oxidases use either c-type cytochromes or quinols as electron donors Aquifex aeolicus
additional information the enzyme can be reduced by ubiquinol, but it alone can also be reduced by decylubiquinol and N,N,N',N'-tetramethyl-4-phenylenediamine/ascorbate in the presence of cyanide Aquifex aeolicus