Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.10.3.1 extracted from

  • Khan, K.M.; Maharvi, G.M.; Khan, M.T.H.; Shaikh, A.J.; Perveen, S.; Begum, S.; Choudhary, M.I.
    Tetraketones: a new class of tyrosinase inhibitors (2006), Bioorg. Med. Chem., 14, 344-351.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
3-aminophenyl-2,2'-methylenebis-(5,5-dimethylcyclohexane-1,3-dione) IC50: 0.0021 mM Agaricus bisporus
3-aminophenyl-2,2'-methylenebis-(cyclohexane-1,3-dione) IC50: 0.00219 mM Agaricus bisporus
3-chlorophenyl-2,2'-methylenebis-(5,5-dimethylcyclohexane-1,3-dione) IC50: 0.0032 mM Agaricus bisporus
kojic acid IC50: 0.016.67 mM Agaricus bisporus
L-mimosine IC50: 0.00368 mM Agaricus bisporus
additional information synthesis and evaluation of several tetraketones with variable substituents at C-7, IC50 values, overview Agaricus bisporus
phenyl-2,2'-methylenebis-(5,5-dimethylcyclohexane-1,3-dione) IC50: 0.0026 mM Agaricus bisporus

Organism

Organism UniProt Comment Textmining
Agaricus bisporus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
Agaricus bisporus
-

Synonyms

Synonyms Comment Organism
More cf. 1.14.18.1 Agaricus bisporus
polyphenol oxidase
-
Agaricus bisporus
PPO
-
Agaricus bisporus
tyrosinase
-
Agaricus bisporus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0021
-
IC50: 0.0021 mM Agaricus bisporus 3-aminophenyl-2,2'-methylenebis-(5,5-dimethylcyclohexane-1,3-dione)
0.00219
-
IC50: 0.00219 mM Agaricus bisporus 3-aminophenyl-2,2'-methylenebis-(cyclohexane-1,3-dione)
0.0026
-
IC50: 0.0026 mM Agaricus bisporus phenyl-2,2'-methylenebis-(5,5-dimethylcyclohexane-1,3-dione)
0.0032
-
IC50: 0.0032 mM Agaricus bisporus 3-chlorophenyl-2,2'-methylenebis-(5,5-dimethylcyclohexane-1,3-dione)
0.00368
-
IC50: 0.00368 mM Agaricus bisporus L-mimosine
0.016
-
IC50: 0.016.67 mM Agaricus bisporus kojic acid