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Literature summary for 1.1.99.21 extracted from

  • Selvaraj, C.; Krishnasamy, G.; Jagtap, S.; Patel, S.; Dhiman, S.; Kim, T.; Singh, S.; Lee, J.
    Structural insights into the binding mode of D-sorbitol with sorbitol dehydrogenase using QM-polarized ligand docking and molecular dynamics simulations (2016), Biochem. Eng. J., 114, 244-256.
No PubMed abstract available
Search for more literature for 1.1.99.21

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information protein-ligand molecular docking and thermodynamics, overview Gluconobacter oxydans

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane membrane-bound dehydrogenase Gluconobacter oxydans 16020
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
53580
-
-
 Gluconobacter oxydans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-sorbitol + acceptor Gluconobacter oxydans
-
 L-sorbose + reduced acceptor
-
 ?

Organism

Organism UniProt Comment Textmining
Gluconobacter oxydans
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-sorbitol + acceptor
-
 Gluconobacter oxydans L-sorbose + reduced acceptor
-
 ?
additional information binding mode of D-sorbitol with sorbitol dehydrogenase using QM-polarized ligand docking and molecular dynamics simulations, His302, Met366, and Asp368 actively participate in D-sorbitol binding, H302 directly forms hydrogen bonds with D-sorbitol and the role of His302 is to hold the D-sorbitol, overview Gluconobacter oxydans ?
-
 ?

Subunits

Subunits Comment Organism
? x * 53580, about, sequence calculation Gluconobacter oxydans
More structure analysis by QM-polarized ligand docking and molecular dynamics simulations, modelling, overview Gluconobacter oxydans

Synonyms

Synonyms Comment Organism
D-sorbitol dehydrogenase
-
 Gluconobacter oxydans
SDH
-
 Gluconobacter oxydans

General Information

General Information Comment Organism
malfunction mutation of His302 results in the denaturation of protein structure and loss of stability Gluconobacter oxydans
metabolism membrane-bound D-sorbitol dehydrogenase is involved in the biotransformation of D-sorbitol to L-sorbose Gluconobacter oxydans
additional information sequence alignment-based homology modeling using the structure of NAD-bound sorbitol dehydrogenase, EC 1.1.1.14, with UniProt ID Q9KWR5 as template Gluconobacter oxydans