Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(4-(2-methoxyethyl)piperazin-1-yl)(6-methyl-7-nitro-5-(trifluoromethyl)benzo[d]thiazol-2-yl)methanone | - |
Mycobacterium tuberculosis | |
(6-methyl-7-nitro-5-(trifluoromethyl)benzo[d]thiazol-2-yl)(piperidin-1-yl)methanone | - |
Mycobacterium tuberculosis | |
(S)-(2-(6-methyl-7-nitro-5-(trifluoromethyl)benzo[d]thiazol-2-yl)-4,5-dihydrooxazol-4-yl)(pyrrolidin-1-yl)methanone | - |
Mycobacterium tuberculosis | |
(S)-(2-(7-nitro-5-(trifluoromethyl)benzo[d]thiazol-2-yl)-4,5-dihydrooxazol-4-yl)(pyrrolidin-1-yl)methanone | - |
Mycobacterium tuberculosis | |
(S)-7-nitro-2-(1-oxo-1-(pyrrolidin-1-yl)propan-2-ylcarbamoyl)-5-(trifluoromethyl)benzo[d]thiazole 3-oxide | - |
Mycobacterium tuberculosis | |
(S)-N-(3-hydroxy-1-oxo-1-(pyrrolidin-1-yl)propan-2-yl)-6-methyl-7-nitro-5-(trifluoromethyl)benzo[d]thiazole-2-carboxamide | - |
Mycobacterium tuberculosis | |
(S)-N-(4-hydroxy-1-oxo-1-(piperidin-1-yl)butan-2-yl)-6-methyl-7-nitro-5-(trifluoromethyl)benzo[d]thiazole-2-carboxamide | - |
Mycobacterium tuberculosis | |
2-(4,5-dihydrooxazol-2-yl)-7-nitro-5-(trifluoromethyl)benzo[d]thiazole 3-oxide | - |
Mycobacterium tuberculosis | |
2-(4-(2-methoxyethyl)piperazine-1-carbonyl)-7-nitro-5-(trifluoromethyl)benzo[d]thiazole 3-oxide | - |
Mycobacterium tuberculosis | |
2-(6-methyl-7-nitro-5-(trifluoromethyl)benzo[d]thiazol-2-yl)-4,5-dihydrooxazole | - |
Mycobacterium tuberculosis | |
2-(7-nitro-5-(trifluoromethyl)benzo[d]thiazol-2-yl)-4,5-dihydrooxazole | - |
Mycobacterium tuberculosis | |
2-(methoxymethyl)-7-nitro-5-(trifluoromethyl)benzo[d]thiazole | - |
Mycobacterium tuberculosis | |
2-(piperidine-1-carbonyl)-5-(trifluoromethyl)benzo[d]thiazol-7-ylboronic acid | - |
Mycobacterium tuberculosis | |
2-(piperidine-1-carbonyl)-5-(trifluoromethyl)benzo[d]thiazole-7-carbonitrile | - |
Mycobacterium tuberculosis | |
2-(piperidine-1-carbonyl)-5-(trifluoromethyl)benzo[d]thiazole-7-carboxylic acid | - |
Mycobacterium tuberculosis | |
3-(2-(piperidine-1-carbonyl)-5-(trifluoromethyl)benzo[d]thiazol-7-yl)-1,2,3-oxadiazol-3-ium-5-olate | - |
Mycobacterium tuberculosis | |
4-((2-methoxyethyl)piperazin-1-yl)(7-nitro-5-(trifluoromethyl)benzo[d]thiazol-2-yl)methanone | - |
Mycobacterium tuberculosis | |
4-((7-nitro-5-(trifluoromethyl)benzo[d]thiazol-2-yl)methyl)morpholine | - |
Mycobacterium tuberculosis | |
6-methyl-7-nitro-N-(pyridin-2-ylmethyl)-5-(trifluoromethyl)benzo[d]thiazole-2-carboxamide | - |
Mycobacterium tuberculosis | |
7-nitro-2-(piperidine-1-carbonyl)-5-(trifluoromethyl)benzo[d]thiazole 3-oxide | - |
Mycobacterium tuberculosis | |
7-nitro-2-(piperidine-1-carbonyl)benzo[d]thiazole-5-carbonitrile | - |
Mycobacterium tuberculosis | |
7-nitro-2-(pyridin-2-ylmethylcarbamoyl)-5-(trifluoromethyl)benzo[d]thiazole 3-oxide | - |
Mycobacterium tuberculosis | |
7-nitro-2-(pyridin-3-ylmethylcarbamoyl)-5-(trifluoromethyl)benzo[d]thiazole 3-oxide | - |
Mycobacterium tuberculosis | |
7-nitro-5-((trifluoromethyl)-1,3-benzothiazol-2-yl)-piperidin-1-ylmethanone | - |
Mycobacterium tuberculosis | |
7-nitro-N-(pyridin-2-ylmethyl)-5-(trifluoromethyl)benzo[d]thiazole-2-carboxamide | - |
Mycobacterium tuberculosis | |
BTZ043 | - |
Mycobacterium tuberculosis | |
morpholino(7-nitro-5-(trifluoromethyl)benzo[d]thiazol-2-yl)methanone | - |
Mycobacterium tuberculosis | |
N-(pyridin-2-ylmethyl)-5-(trifluoromethyl)benzo[d]thiazole-2-carboxamide | - |
Mycobacterium tuberculosis | |
N-methyl-7-nitro-2-(piperidine-1-carbonyl)benzo[d]thiazole-5-carboxamide | - |
Mycobacterium tuberculosis | |
N-[(2S)-3-hydroxy-1-oxo-1-pyrrolidin-1-ylpropan-2-yl]-7-nitro-5-(trifluoromethyl)-1,3-benzothiazole-2-carboxamide | - |
Mycobacterium tuberculosis | |
PBTZ169 | - |
Mycobacterium tuberculosis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
trans,octacis-decaprenylphospho-beta-D-ribofuranose + FAD | Mycobacterium tuberculosis | - |
trans,octacis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose + FADH2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | P9WJF1 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
trans,octacis-decaprenylphospho-beta-D-ribofuranose + FAD | - |
Mycobacterium tuberculosis | trans,octacis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose + FADH2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
decaprenylphosphoryl-beta-D-ribose 2'-oxidase | - |
Mycobacterium tuberculosis |
DprE1 | - |
Mycobacterium tuberculosis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Mycobacterium tuberculosis |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000026 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 7-nitro-2-(pyridin-2-ylmethylcarbamoyl)-5-(trifluoromethyl)benzo[d]thiazole 3-oxide | |
0.000027 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 2-(4-(2-methoxyethyl)piperazine-1-carbonyl)-7-nitro-5-(trifluoromethyl)benzo[d]thiazole 3-oxide | |
0.00006 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | (S)-7-nitro-2-(1-oxo-1-(pyrrolidin-1-yl)propan-2-ylcarbamoyl)-5-(trifluoromethyl)benzo[d]thiazole 3-oxide | |
0.000095 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 7-nitro-2-(piperidine-1-carbonyl)-5-(trifluoromethyl)benzo[d]thiazole 3-oxide | |
0.000213 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 7-nitro-5-((trifluoromethyl)-1,3-benzothiazol-2-yl)-piperidin-1-ylmethanone | |
0.000247 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 4-((2-methoxyethyl)piperazin-1-yl)(7-nitro-5-(trifluoromethyl)benzo[d]thiazol-2-yl)methanone | |
0.000276 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 2-(4,5-dihydrooxazol-2-yl)-7-nitro-5-(trifluoromethyl)benzo[d]thiazole 3-oxide | |
0.0003 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | morpholino(7-nitro-5-(trifluoromethyl)benzo[d]thiazol-2-yl)methanone | |
0.000349 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | N-[(2S)-3-hydroxy-1-oxo-1-pyrrolidin-1-ylpropan-2-yl]-7-nitro-5-(trifluoromethyl)-1,3-benzothiazole-2-carboxamide | |
0.000452 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 7-nitro-N-(pyridin-2-ylmethyl)-5-(trifluoromethyl)benzo[d]thiazole-2-carboxamide | |
0.000654 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | (S)-(2-(7-nitro-5-(trifluoromethyl)benzo[d]thiazol-2-yl)-4,5-dihydrooxazol-4-yl)(pyrrolidin-1-yl)methanone | |
0.0012 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | (S)-(2-(6-methyl-7-nitro-5-(trifluoromethyl)benzo[d]thiazol-2-yl)-4,5-dihydrooxazol-4-yl)(pyrrolidin-1-yl)methanone | |
0.0012 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | (S)-N-(3-hydroxy-1-oxo-1-(pyrrolidin-1-yl)propan-2-yl)-6-methyl-7-nitro-5-(trifluoromethyl)benzo[d]thiazole-2-carboxamide | |
0.0012 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | (S)-N-(4-hydroxy-1-oxo-1-(piperidin-1-yl)butan-2-yl)-6-methyl-7-nitro-5-(trifluoromethyl)benzo[d]thiazole-2-carboxamide | |
0.0012 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 6-methyl-7-nitro-N-(pyridin-2-ylmethyl)-5-(trifluoromethyl)benzo[d]thiazole-2-carboxamide | |
0.0017 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | (4-(2-methoxyethyl)piperazin-1-yl)(6-methyl-7-nitro-5-(trifluoromethyl)benzo[d]thiazol-2-yl)methanone | |
0.0018 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 7-nitro-2-(piperidine-1-carbonyl)benzo[d]thiazole-5-carbonitrile | |
0.0022 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | (6-methyl-7-nitro-5-(trifluoromethyl)benzo[d]thiazol-2-yl)(piperidin-1-yl)methanone | |
0.0039 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 2-(6-methyl-7-nitro-5-(trifluoromethyl)benzo[d]thiazol-2-yl)-4,5-dihydrooxazole | |
0.0052 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 4-((7-nitro-5-(trifluoromethyl)benzo[d]thiazol-2-yl)methyl)morpholine | |
0.0059 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 2-(methoxymethyl)-7-nitro-5-(trifluoromethyl)benzo[d]thiazole | |
0.0282 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 3-(2-(piperidine-1-carbonyl)-5-(trifluoromethyl)benzo[d]thiazol-7-yl)-1,2,3-oxadiazol-3-ium-5-olate | |
0.053 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | N-methyl-7-nitro-2-(piperidine-1-carbonyl)benzo[d]thiazole-5-carboxamide | |
0.1 | - |
IC50 above 0.1 mM, pH and temperature not specified in the publication | Mycobacterium tuberculosis | 2-(piperidine-1-carbonyl)-5-(trifluoromethyl)benzo[d]thiazole-7-carboxylic acid | |
0.1 | - |
IC50 above 0.1 mM, pH and temperature not specified in the publication | Mycobacterium tuberculosis | N-(pyridin-2-ylmethyl)-5-(trifluoromethyl)benzo[d]thiazole-2-carboxamide |