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Literature summary for 1.1.3.8 extracted from

  • Puskas, F.; Braun, L.; Csala, M.; Kardon, T.; Marcolongo, P.; Benedetti, A.; Mandl, J.; Banhegyi, G.
    Gulonolactone oxidase activity-dependent intravesicular glutathione oxidation in rat liver microsomes (1998), FEBS Lett., 430, 293-296.
    View publication on PubMed
Search for more literature for 1.1.3.8

Activating Compound

Activating Compound Comment Organism Structure
alamethicin 0.1 mg per mg protein 7.5% activation Rattus norvegicus
Triton X-100 addition to intact microsomes results in a concentration dependent increase in gulonolactone oxidase activity, 38% activation with 5 mg Triton X-100 per mg protein Rattus norvegicus

General Stability

General Stability Organism
highly resistant to proteolytic treatment both in native and in disrupted microsomes Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome integral membrane protein in the endoplasmic reticulum Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-gulono-1,4-lactone + O2 Rattus norvegicus
-
 L-xylo-hex-3-ulonolactone + H2O2
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
L-gulono-1,4-lactone + O2 = L-xylo-hex-2-ulono-1,4-lactone + H2O2 product isomerizes spontaneously to L-ascorbate Rattus norvegicus
a

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-gulono-1,4-lactone + O2
-
 Rattus norvegicus L-xylo-hex-3-ulonolactone + H2O2
-
 ?
L-gulono-1,4-lactone + O2
-
 Rattus norvegicus L-xylo-hex-3-ulonolactone + H2O2 product isomerizes spontaneously to L-ascorbate ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
-
 Rattus norvegicus