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Literature summary for 1.1.3.6 extracted from

  • Smith, A.G.; Brooks, C.J.W.
    Studies of the substrate specificity of cholesterol oxidase from Nocardia erythropolis in the oxidation of 3-hydroxy steroids (1975), Biochem. Soc. Trans., 3, 675-677.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0012
-
26-Hydroxycholesterol 5-androstene-3beta,17beta-diol Nocardia erythropolis
0.0014
-
25-Hydroxy-27-norcholesterol
-
Nocardia erythropolis
0.0023
-
5alpha-Cholestan-3beta-ol
-
Nocardia erythropolis
0.0028
-
5alpha-Cholest-8(14)-en-3beta-ol
-
Nocardia erythropolis
0.0029
-
cholesterol
-
Nocardia erythropolis
0.0031
-
17beta-Hydroxymethyl-5-androsten-3beta-ol
-
Nocardia erythropolis
0.0037
-
5-pregnene-3beta,20beta-diol
-
Nocardia erythropolis
0.0048
-
5-Cholene-3beta,24-diol
-
Nocardia erythropolis
0.0055
-
5,7-cholestadien-3beta-ol
-
Nocardia erythropolis
0.0075
-
4,4-Dimethylcholesterol
-
Nocardia erythropolis
0.0093
-
23,24-dinor-5-cholene-3beta,22-diol
-
Nocardia erythropolis
0.0107
-
5alpha-cholest-8(14)en-3beta-ol
-
Nocardia erythropolis
0.0126
-
4alpha-Methylcholesterol
-
Nocardia erythropolis
0.0284
-
4beta-methylcholesterol
-
Nocardia erythropolis
0.124
-
20,25-Diazacholesterol
-
Nocardia erythropolis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cholesterol + O2 Nocardia erythropolis
-
cholest-5-en-3-one + H2O2
-
?

Organism

Organism UniProt Comment Textmining
Nocardia erythropolis
-
-
-

Reaction

Reaction Comment Organism Reaction ID
cholesterol + O2 = cholest-5-en-3-one + H2O2 bifunctional enzyme, catalyzes both the oxidation of DELTA5-ene-3beta hydroxysteroids with a trans A-B ring junction to the corresponding DELTA5-3-ketosteroid with the reduction of oxygen to hydrogen peroxide, and the isomerization to the DELTA4-3-ketosteroid Nocardia erythropolis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
17beta-hydroxymethyl-5-androsten-3beta-ol + O2
-
Nocardia erythropolis 17beta-hydroxymethyl-5-androsten-3-one + H2O2
-
?
20,25-diazacholesterol + O2
-
Nocardia erythropolis 20,25-diazacholest-4-en-3-one + H2O2
-
?
23,24-dinor-5-cholen-3beta,22-diol + O2
-
Nocardia erythropolis 23,24-dinor-5-cholen-22-ol-3-one + H2O2
-
?
23,24-dinor-5-cholene-3beta,22-diol + O2
-
Nocardia erythropolis 23,24-dinor-5-cholen-22-ol-3-one + H2O2
-
r
25-hydroxy-27-norcholesterol + O2
-
Nocardia erythropolis ?
-
?
26-hydroxycholesterol + O2
-
Nocardia erythropolis 26-hydroxycholest-5-en-3-one + H2O2
-
?
4,4-dimethylcholesterol + O2
-
Nocardia erythropolis 4,4-dimethylcholest-5-en-3-one
-
?
4alpha-methylcholesterol + O2
-
Nocardia erythropolis 4alpha-methylcholest-5-en-3-one + H2O2
-
?
4beta-methylcholesterol + O2
-
Nocardia erythropolis 4beta-methylcholest-5-en-3-one + H2O2
-
?
5,7-cholestadien-3beta-ol + O2
-
Nocardia erythropolis 5,7-cholestadien-3-one + H2O2
-
?
5-androstene-3beta,17beta-diol + O2
-
Nocardia erythropolis 5-androsten-17beta-ol-3-one + H2O2
-
?
5-cholene-3beta,24-diol + O2
-
Nocardia erythropolis 5-cholen-24-ol-3-one + H2O2
-
?
5-pregnen-3beta,20beta-diol + O2
-
Nocardia erythropolis 5-pregnen-20beta-ol-3-one + H2O2
-
?
5alpha-cholest-8(14)-en-3beta-ol + O2
-
Nocardia erythropolis 5alpha-cholest-8(14)-en-3-one + H2O2
-
?
5alpha-cholestan-3beta-ol + O2
-
Nocardia erythropolis 5alpha-cholestan-3-one + H2O2
-
?
cholesterol + O2 enzyme specifically oxidizes 3beta-hydroxy groups in steroids Nocardia erythropolis cholest-4-en-3-one + H2O2
-
?
cholesterol + O2
-
Nocardia erythropolis cholest-5-en-3-one + H2O2
-
?