Any feedback?
Literature summary for 1.1.3.15 extracted from
- Potent and selective inhibitors of long chain l-2-hydroxy acid oxidase reduced blood pressure in DOCA salt-treated rats (2011), ACS Med. Chem. Lett., 2, 919-923.
Application
| Application | Comment | Organism |
|---|---|---|
| drug development | isozyme Hao2 is a target for drug development in high blood pressure | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 3-methyl-4-(2-phenylethyl)-1H-pyrazole-5-carboxylic acid | - |
Rattus norvegicus |  |
| 4-(1-benzothiophen-2-ylmethyl)-3-methyl-1H-pyrazole-5-carboxylic acid | - |
Rattus norvegicus | |
| 4-(4-fluorophenyl)-3-methyl-1H-pyrazole-5-carboxylic acid | 35% inhibition at 0.010 mM | Rattus norvegicus | |
| 4-(biphenyl-3-ylmethyl)-3-methyl-1H-pyrazole-5-carboxylic acid | - |
Rattus norvegicus | |
| 4-[(4'-fluorobiphenyl-3-yl)methyl]-3-methyl-1H-pyrazole-5-carboxylic acid | - |
Rattus norvegicus | |
| additional information | treatment with 4-[(4'-fluorobiphenyl-3-yl)methyl]-3-methyl-1H-pyrazole-5-carboxylic acid or 4-(1-benzothiophen-2-ylmethyl)-3-methyl-1H-pyrazole-5-carboxylic acid results in a significant reduction or attenuation of blood pressure in an established or developing model of hypertension, deoxycorticosterone acetate-treated rats | Rattus norvegicus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| peroxisome | - |
Rattus norvegicus | 5777 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 39000 | - |
x * 39000, about, sequence calculation | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Rattus norvegicus | - |
| liver | - |
Rattus norvegicus | - |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 39000, about, sequence calculation | Rattus norvegicus |
| More | molecular modeling studies using the rat Hao2 crystal structure, PDB ID 1TB3, overview | Rattus norvegicus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Hao2 | - |
Rattus norvegicus |
| L-2-hydroxy acid oxidase | - |
Rattus norvegicus |
| long chain l-2-hydroxy acid oxidase | - |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FMN | - |
Rattus norvegicus | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0003 | - |
pH and temperature not specified in the publication | Rattus norvegicus | 4-[(4'-fluorobiphenyl-3-yl)methyl]-3-methyl-1H-pyrazole-5-carboxylic acid | |
| 0.0003 | - |
pH and temperature not specified in the publication | Rattus norvegicus | 4-(1-benzothiophen-2-ylmethyl)-3-methyl-1H-pyrazole-5-carboxylic acid | |
| 0.0091 | - |
pH and temperature not specified in the publication | Rattus norvegicus | 4-(biphenyl-3-ylmethyl)-3-methyl-1H-pyrazole-5-carboxylic acid | |
| 427 | - |
pH and temperature not specified in the publication | Rattus norvegicus | 3-methyl-4-(2-phenylethyl)-1H-pyrazole-5-carboxylic acid | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | pharmacological role of the enzyme in the management of blood pressure | Rattus norvegicus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
