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Literature summary for 1.1.2.3 extracted from

  • Tabacchi, G.; Zucchini, D.; Caprini, G.; Gamba, A.; Lederer, F.; Vanoni, M.A.; Fois, E.
    L-lactate dehydrogenation in flavocytochrome b2: a first principles molecular dynamics study (2009), FEBS J., 276, 2368-2380.
    View publication on PubMed
Search for more literature for 1.1.2.3

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-lactate + ferricytochrome c Saccharomyces cerevisiae
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 pyruvate + ferrocytochrome c + H+
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 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae P00175
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-lactate + ferricytochrome c
-
 Saccharomyces cerevisiae pyruvate + ferrocytochrome c + H+
-
 ?
L-lactate + ferricytochrome c molecular dynamics studies on active-site models of flavocytochrome b2 in complex with the substrate for analysis of the mechanism of the enzyme-catalyzed L-lactate oxidation reaction, overview. In the calculated enzyme-substrate model complex, the l-lactate alpha-OH hydrogen is hydrogen bonded to the activesite base H373 Ne, whereas the Halpha is directed towards flavin N5, suggesting that the reaction is initiated by a-OH proton abstraction Saccharomyces cerevisiae pyruvate + ferrocytochrome c + H+
-
 ?
additional information the role of the flavin mononucleotide-ribityl chain 2'OH group in maintaining the conserved K349 in a geometry favoring flavin reduction, of an active site water molecule belonging to a S371-Wat-D282-H373 hydrogen-bonded chain, which modulates the reactivity of the key catalytic histidine, and of the flavin C4a-C10a locus in facilitating proton transfer from the substrate to the active-site base, favoring the initial step of the lactate dehydrogenation reaction Saccharomyces cerevisiae ?
-
 ?

Subunits

Subunits Comment Organism
homotetramer enzyme-substrate structure analysis during thr reaction cycle, overview Saccharomyces cerevisiae

Synonyms

Synonyms Comment Organism
Fcb2
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 Saccharomyces cerevisiae
flavocytochrome b2
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 Saccharomyces cerevisiae
L-lactate: cytochrome c oxidoreductase
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 Saccharomyces cerevisiae

Cofactor

Cofactor Comment Organism Structure
cytochrome c
-
 Saccharomyces cerevisiae