Literature summary for 1.1.1.B40 extracted from

Green, B.B.; Armstrong, D.A.; Lesseur, C.; Paquette, A.G.; Guerin, D.J.; Kwan, L.E.; Marsit, C.J.
The role of placental 11-beta hydroxysteroid dehydrogenase type 1 and type 2 methylation on gene expression and infant birth weight (2015), Biol. Reprod., 92, 149 .

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Cloned(Commentary)

Cloned (Comment)	Organism
gene HSD11B1, variation exists in placental DNA methylation of HSD11B1, the variation is associated with mRNA expression of the gene, real-time PCR expression analysis. No correlation between HSD11B1 CpG1 and expression, and a strong positive correlation between CpG2 and expression. HSD11B1 gene expression is positively correlated with a single CpG site	Homo sapiens
gene HSD11B2, variation exists in placental DNA methylation of HSD11B2, the variation is associated with mRNA expression of the gene, real-time PCR expression analysis. Sex-specific correlation between HSD11B2 methylation levels and expression, with females displaying a much stronger correlation between the two factors with no correlation for males, there is no sex-specific role of methylation in infant birth weight in either time points in pregnancy. HSD11B2 expression is negatively correlated with the mean methylation of four CpG sites within its promoter	Homo sapiens

Cloned (Comment)

Organism

gene HSD11B1, variation exists in placental DNA methylation of HSD11B1, the variation is associated with mRNA expression of the gene, real-time PCR expression analysis. No correlation between HSD11B1 CpG1 and expression, and a strong positive correlation between CpG2 and expression. HSD11B1 gene expression is positively correlated with a single CpG site

Homo sapiens

gene HSD11B2, variation exists in placental DNA methylation of HSD11B2, the variation is associated with mRNA expression of the gene, real-time PCR expression analysis. Sex-specific correlation between HSD11B2 methylation levels and expression, with females displaying a much stronger correlation between the two factors with no correlation for males, there is no sex-specific role of methylation in infant birth weight in either time points in pregnancy. HSD11B2 expression is negatively correlated with the mean methylation of four CpG sites within its promoter

Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P28845	-	-
Homo sapiens	P80365	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
placenta	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
11-beta hydroxysteroid dehydrogenase type 1	-	Homo sapiens
11-beta hydroxysteroid dehydrogenase type 2	-	Homo sapiens
HSD11B type 1	-	Homo sapiens
HSD11B type 2	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	the placenta acts as a master regulator for the fetal environment, mediating intrauterine exposures to stress through the activity of genes regulating glucocorticoids, including the 11beta-hydroxysteroid dehydrogenase (HSD11B) type 1 and 2 genes, variation in the genes are associated with infant birth weight. A significant association between methylation at a single CpG site within HSD11B1 and being born large for gestational age is detected. Correlations between methylation and gene expression. Methylation at a single CpG site within HSD11B1 is associated with infant birth weight, and that methylation at several different sites is correlated with gene expression. There is no sex-specific role of methylation in infant birth weight in either time points in pregnancy	Homo sapiens
physiological function	the placenta acts as a master regulator for the fetal environment, mediating intrauterine exposures to stress through the activity of genes regulating glucocorticoids, including the 11beta-hydroxysteroid dehydrogenase (HSD11B) type 1 and 2 genes, variation in the genes are associated with infant birth weight. Correlations between methylation and gene expression, including sex-specific transcriptional regulation of HSD11B2	Homo sapiens