Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate | IC50 in the presence of NADP+: 0.12 mM, IC50 in the presence of NAD+: 5.6 mM; i.e. CHAPS | Homo sapiens | |
3beta-hydroxy-11-oxo-18beta-olean-12-en-30-oic-acid | IC50 in the presence of NAD+: 0.000097 mM, IC50 in the presence of NADP+: 0.0003 mM; i.e. glycyrrhetinic acid | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000044 | - |
NAD+ | reduction of corticosterone, pH and temperature not specified in the publication | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
11beta,21-dihydroxypregn-4-en-3,20-dione + NAD+ | Homo sapiens | i.e. corticosterone, clear but not exclusive preference for NAD+, only oxidative activity | 21-hydroxy-pregn-4-en-3,11,20-trione + NADH | - |
ir |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
placenta | constitutes an important barrier for 11-OH steroids during pregnancy between maternal and fetal organism, presence of two isoforms | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
11beta,21-dihydroxypregn-4-en-3,20-dione + NAD+ | i.e. corticosterone, clear but not exclusive preference for NAD+, only oxidative activity | Homo sapiens | 21-hydroxy-pregn-4-en-3,11,20-trione + NADH | - |
ir |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | clear but not exclusive preference for NAD+ | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000097 | - |
pH and temperature not specified in the publication | Homo sapiens | 3beta-hydroxy-11-oxo-18beta-olean-12-en-30-oic-acid | |
5.6 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate |