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Literature summary for 1.1.1.9 extracted from
- NAD+-dependent xylitol dehydrogenase (xdhA) and L-arabitol-4-dehydrogenase (ladA) deletion mutants of Aspergillus oryzae for improved xylitol production (2013), Biotechnol. Lett., 35, 769-777.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene xdhA | Aspergillus oryzae |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | generation of xdhA and ladA deletion mutants and double-deletion mutant, that show decreased dehydrogenase activities and increased xylitol production from D-xylose compared to the KBN616 wild-type strain, overview | Aspergillus oryzae |
| additional information | construction of deletion mutants of xdhA and ladA-xdhA, to generate mutants with decreased dehydrogenase activities and increased xylitol production. Genomic DNA from Aspergillus oryzae strain KBN616 is used as the template for amplification of the three xdhA and ladA inserts. Activities of xylitol dehydrogenase and xylose reductase in the mutant strains, phenotype, overview | Aspergillus oryzae |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| xylitol + NAD+ | Aspergillus oryzae | - |
D-xylulose + NADH + H+ | - |
r |  |
| xylitol + NAD+ | Aspergillus oryzae | - |
D-xylulose + NADH + H+ | - |
? | |
| xylitol + NAD+ | Aspergillus oryzae KBN616 | - |
D-xylulose + NADH + H+ | - |
r | |
| xylitol + NAD+ | Aspergillus oryzae KBN616 | - |
D-xylulose + NADH + H+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Aspergillus oryzae | - |
gene xdhA | - |
| Aspergillus oryzae | Q86ZV0 | and uracil auxotroph derivative strain P4 | - |
| Aspergillus oryzae KBN616 | - |
gene xdhA | - |
| Aspergillus oryzae KBN616 | Q86ZV0 | and uracil auxotroph derivative strain P4 | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| xylitol + NAD+ | - |
Aspergillus oryzae | D-xylulose + NADH + H+ | - |
r | |
| xylitol + NAD+ | - |
Aspergillus oryzae | D-xylulose + NADH + H+ | - |
? | |
| xylitol + NAD+ | - |
Aspergillus oryzae KBN616 | D-xylulose + NADH + H+ | - |
r | |
| xylitol + NAD+ | - |
Aspergillus oryzae KBN616 | D-xylulose + NADH + H+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| D-xylulose reductase A | - |
Aspergillus oryzae |
| XDH | - |
Aspergillus oryzae |
| xdhA | - |
Aspergillus oryzae |
| xylitol dehydrogenase | - |
Aspergillus oryzae |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
assay at | Aspergillus oryzae |
| 30 | - |
assay at | Aspergillus oryzae |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
assay at | Aspergillus oryzae |
| 7.5 | - |
assay at | Aspergillus oryzae |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Aspergillus oryzae | |
| NADH | - |
Aspergillus oryzae | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | deletin of gene xdhA and gene ladA and or both lead mutants with decreased dehydrogenase activities and increased xylitol production, overview | Aspergillus oryzae |
| additional information | xylitol production of wild-type and mutant strains, overview | Aspergillus oryzae |
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Release 2023.1 (January 2023)
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