Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-hydroxy-3-methylglutarate | - |
Pseudomonas mevalonii | |
4-hydroxybutyrate | - |
Pseudomonas mevalonii | |
acetoacetate | - |
Pseudomonas mevalonii | |
beta-hydroxybutyrate | - |
Pseudomonas mevalonii | |
lovastin | - |
Pseudomonas mevalonii | |
mevalonate | - |
Pseudomonas mevalonii |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Pseudomonas mevalonii | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
(R)-mevalonate + CoA + 2 NAD+ = 3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+ | There are two classes of enzyme, the third enzyme of the mevalonate pathway of isopentenyl diphosphate biosynthesis: the class I enzymes of eukaryotes and the class II enzymes of certain eubacteria | Pseudomonas mevalonii |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3-hydroxy-3-methylglutaryl-CoA + NADH + H+ | - |
Pseudomonas mevalonii | mevalonate + CoA + NAD+ | - |
r |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Pseudomonas mevalonii | |
NADH | - |
Pseudomonas mevalonii |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.26 | - |
mevalonate | standard conditions, substrate inhibition | Pseudomonas mevalonii | |
0.28 | - |
lovastin | competive inhibition with respect to mevanolate | Pseudomonas mevalonii | |
0.53 | - |
lovastin | competive inhibition with respect to 3-hydroxy-3-methylglutaryl-CoA | Pseudomonas mevalonii | |
0.8 | - |
beta-hydroxybutyrate | standard conditions, inhibition by substrate analog | Pseudomonas mevalonii | |
3 | - |
acetoacetate | standard conditions, inhibition by substrate analog | Pseudomonas mevalonii | |
4.5 | - |
3-hydroxy-3-methylglutarate | standard conditions, inhibition by substrate analog | Pseudomonas mevalonii | |
16 | - |
lovastin | non-competive inhibition with respect to NADH | Pseudomonas mevalonii | |
35 | - |
lovastin | non-competive inhibition with respect to NAD+ | Pseudomonas mevalonii | |
35 | - |
4-hydroxybutyrate | standard conditions, inhibition by substrate analog | Pseudomonas mevalonii |