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Literature summary for 1.1.1.86 extracted from

  • Wang, B.; Li, Y.; Wang, J.; Ma, Y.; Li, Z.
    Molecular design, synthesis and biological activities of amidines as new ketol-acid reductoisomerase inhibitors (2008), Chin. Chem. Lett., 19, 651-654.
No PubMed abstract available
Search for more literature for 1.1.1.86

Application

Application Comment Organism
drug development the enzyme is a target for herbicide drug development, computer-aided drug design Spinacia oleracea

Inhibitors

Inhibitors Comment Organism Structure
2-dimethylphosphinoyl-2-hydroxyacetate i.e. Hoe 704, potent competitive inhibitor in vitro but weak in vivo Spinacia oleracea
4,4'-(pentamethylenedioxy)dibenzamidne bis(2-hydroxyethanesulfonate) binding structure and inhibition mechanism, overview Escherichia coli
4,4'-(pentamethylenedioxy)dibenzamidne bis(2-hydroxyethanesulfonate) binding structure and inhibition mechanism, overview Oryza sativa
4-(2,4-dichlorophenoxy)benzenecarboximidamide
-
 Oryza sativa
4-(2-fluorophenoxy)benzenecarboximidamide
-
 Oryza sativa
4-(3-chlorophenoxy)benzenecarboximidamide
-
 Oryza sativa
4-(4-chlorophenoxy)benzenecarboximidamide
-
 Oryza sativa
4-phenoxybenzenecarboximidamide
-
 Oryza sativa
cyclopropane-1,1-dicarboxylate
-
 Oryza sativa
additional information computer-aided drug design, overview Escherichia coli
additional information computer-aided drug design, overview Oryza sativa
additional information computer-aided drug design, overview Spinacia oleracea
N'-(5-(3-pyridinyl)-1,3,4-thiadiazol-2-yl)-N-cyclopropyformyl-thiourea
-
 Oryza sativa
N'-(5-(4-chlorophenyl)-1,3,4-thiadiazol-2-yl)-N-cyclopropyformyl-thiourea
-
 Oryza sativa
N'-(5-butyl-1,3,4-thiadiazol-2-yl)-N-cyclopropyformyl-thiourea
-
 Oryza sativa
N'-(5-ethyl-1,3,4-thiadiazol-2-yl)-N-cyclopropyformyl-thiourea
-
 Oryza sativa
N'-(5-heptyl-1,3,4-thiadiazol-2-yl)-N-cyclopropyformyl-thiourea
-
 Oryza sativa
N'-(5-iso-propyl-1,3,4-thiadiazol-2-yl)-N-cyclopropyformyl-thiourea
-
 Oryza sativa
N'-(5-methyl-1,3,4-thiadiazol-2-yl)-N-cyclopropyformyl-thiourea
-
 Oryza sativa
N'-(5-octyl-1,3,4-thiadiazol-2-yl)-N-cyclopropyformyl-thiourea
-
 Oryza sativa
N'-(5-pentyl-1,3,4-thiadiazol-2-yl)-N-cyclopropyformyl-thiourea
-
 Oryza sativa
N'-(5-propyl-1,3,4-thiadiazol-2-yl)-N-cyclopropyformyl-thiourea
-
 Oryza sativa
N-Hydroxy-N-isopropyloxamate i.e. IpOHA, potent competitive inhibitor in vitro but weak in vivo Spinacia oleracea

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Escherichia coli structure-biological activity relationship, overview ?
-
 ?
additional information Spinacia oleracea structure-biological activity relationship, overview ?
-
 ?
additional information Oryza sativa structure-biological activity relationship, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Oryza sativa
-
-
-
Spinacia oleracea
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information structure-biological activity relationship, overview Escherichia coli ?
-
 ?
additional information structure-biological activity relationship, overview Spinacia oleracea ?
-
 ?
additional information structure-biological activity relationship, overview Oryza sativa ?
-
 ?

Synonyms

Synonyms Comment Organism
acetohydroxy acid isomeroreductase
-
 Escherichia coli
acetohydroxy acid isomeroreductase
-
 Spinacia oleracea
acetohydroxy acid isomeroreductase
-
 Oryza sativa
AHIR
-
 Escherichia coli
AHIR
-
 Spinacia oleracea
AHIR
-
 Oryza sativa
KARI
-
 Escherichia coli
KARI
-
 Spinacia oleracea
KARI
-
 Oryza sativa

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.35
-
 4,4'-(pentamethylenedioxy)dibenzamidne bis(2-hydroxyethanesulfonate)
-
 Oryza sativa