Literature summary for 1.1.1.8 extracted from

Orr, A.L.; Ashok, D.; Sarantos, M.R.; Ng, R.; Shi, T.; Gerencser, A.A.; Hughes, R.E.; Brand, M.D.
Novel inhibitors of mitochondrial sn-glycerol 3-phosphate dehydrogenase (2014), PLoS ONE, 9, e89938.

Search for more literature for 1.1.1.8

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	no inhibition of the cytosolic NAD+-linked cGPDH enzyme by cell-permeant small-molecule inhibitors of mitochondrial mGPDH, EC 1.1.5.3, with a core benzimidazole-phenyl-succinamide structure	Oryctolagus cuniculus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Oryctolagus cuniculus	5829	-
soluble	-	Oryctolagus cuniculus	-	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
sn-glycerol 3-phosphate + NAD+	Oryctolagus cuniculus	-	glycerone phosphate + NADH + H+	-	r

Organism

Organism	UniProt	Comment	Textmining
Oryctolagus cuniculus	P08507	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
commercial preparation	purified enzyme	Oryctolagus cuniculus	-
skeletal muscle	-	Oryctolagus cuniculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
sn-glycerol 3-phosphate + NAD+	-	Oryctolagus cuniculus	glycerone phosphate + NADH + H+	-	r
sn-glycerol 3-phosphate + NAD+	NAD+-linked cGPDH can interconvert DHAP and glycerol 3-phosphate	Oryctolagus cuniculus	glycerone phosphate + NADH + H+	-	r

Synonyms

Synonyms	Comment	Organism
cGPdH	-	Oryctolagus cuniculus
cytosolic GPDH	-	Oryctolagus cuniculus
GPD1	-	Oryctolagus cuniculus

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Oryctolagus cuniculus

Cofactor

Cofactor	Comment	Organism	Structure
NAD+	-	Oryctolagus cuniculus
NADH	-	Oryctolagus cuniculus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)