Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.64 extracted from

  • Nakamura, Y.; Hornsby, P.; Casson, P.; Morimoto, R.; Satoh, F.; Xing, Y.; Kennedy, M.; Sasano, H.; Rainey, W.
    Type 5 17ß-hydroxysteroid dehydrogenase (AKR1C3) contributes to testosterone production in the adrenal reticularis (2009), J. Clin. Endocrinol. Metab., 94, 2192-2198.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.1.1.64

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland predominantly expressed in the zona reticularis Homo sapiens
-
liver
-
 Homo sapiens
-
ovary
-
 Homo sapiens
-
testis
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
17beta-hydroxysteroid dehydrogenase type 5
-
 Homo sapiens
AKR1C3
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction AKR1C3 knockdown is accomplished in cultured adrenal cells (H295R) using small interfering RNA. Decreasing adrenal cell expression of AKR1C3 mRNA and protein inhibit testosterone production in the H295R adrenal cell line Homo sapiens