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Literature summary for 1.1.1.64 extracted from

  • Oshima, H.; Ochiai, K.
    On testicular 17beta-hydroxysteroid oxidoreductase product activation of testosterone formation from androstendione in vitro (1973), Biochim. Biophys. Acta, 306, 227-236.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
testosterone 0.023 mM, 2.6fold increase in androstenedione reduction Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0015
-
testosterone enzyme activity in cell-free homogenate, approximate value Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
17beta-estradiol + NADP+ Homo sapiens
-
estrone + NADPH
-
r
17beta-estradiol + NADP+ Oryctolagus cuniculus
-
estrone + NADPH
-
r
testosterone + NADP+ Homo sapiens
-
androst-4-ene-3,17-dione + NADPH + H+
-
r
testosterone + NADP+ Oryctolagus cuniculus
-
androst-4-ene-3,17-dione + NADPH + H+
-
r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Oryctolagus cuniculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
testis
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
17beta-estradiol + NADP+
-
Homo sapiens estrone + NADPH
-
r
17beta-estradiol + NADP+
-
Oryctolagus cuniculus estrone + NADPH
-
r
testosterone + NADP+
-
Homo sapiens androst-4-ene-3,17-dione + NADPH + H+
-
r
testosterone + NADP+
-
Oryctolagus cuniculus androst-4-ene-3,17-dione + NADPH + H+
-
r

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
45
-
sharp drop of activity above Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.8
-
addition of testosterone shifts optimal pH to 7.4-7.8 Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
4 9
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Homo sapiens
NADP+
-
Oryctolagus cuniculus