Activating Compound | Comment | Organism | Structure |
---|---|---|---|
testosterone | 0.023 mM, 2.6fold increase in androstenedione reduction | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0015 | - |
testosterone | enzyme activity in cell-free homogenate, approximate value | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
17beta-estradiol + NADP+ | Homo sapiens | - |
estrone + NADPH | - |
r | |
17beta-estradiol + NADP+ | Oryctolagus cuniculus | - |
estrone + NADPH | - |
r | |
testosterone + NADP+ | Homo sapiens | - |
androst-4-ene-3,17-dione + NADPH + H+ | - |
r | |
testosterone + NADP+ | Oryctolagus cuniculus | - |
androst-4-ene-3,17-dione + NADPH + H+ | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Oryctolagus cuniculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
testis | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
17beta-estradiol + NADP+ | - |
Homo sapiens | estrone + NADPH | - |
r | |
17beta-estradiol + NADP+ | - |
Oryctolagus cuniculus | estrone + NADPH | - |
r | |
testosterone + NADP+ | - |
Homo sapiens | androst-4-ene-3,17-dione + NADPH + H+ | - |
r | |
testosterone + NADP+ | - |
Oryctolagus cuniculus | androst-4-ene-3,17-dione + NADPH + H+ | - |
r |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
45 | - |
sharp drop of activity above | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
5.8 | - |
addition of testosterone shifts optimal pH to 7.4-7.8 | Homo sapiens |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
4 | 9 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Homo sapiens | |
NADP+ | - |
Oryctolagus cuniculus |