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Literature summary for 1.1.1.62 extracted from

  • Nashev, L.G.; Schuster, D.; Laggner, C.; Sodha, S.; Langer, T.; Wolber, G.; Odermatt, A.
    The UV-filter benzophenone-1 inhibits 17beta-hydroxysteroid dehydrogenase type 3: Virtual screening as a strategy to identify potential endocrine disrupting chemicals (2010), Biochem. Pharmacol., 79, 1189-1199.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK-293 cells by transient transfection Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(2,4-dihydroxyphenyl)-phenylmethanone
-
Homo sapiens
2,2',4,4'-tetrahydroxybenzophenone
-
Homo sapiens
3-benzylidene camphor
-
Homo sapiens
4-methylbenzylidene camphor
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
estradiol + NADP+
-
Homo sapiens estrone + NADPH + H+
-
?
estrone + NADPH + H+
-
Homo sapiens estradiol + NADP+
-
?

Synonyms

Synonyms Comment Organism
17beta-HSD1
-
Homo sapiens
17beta-HSD2
-
Homo sapiens
17beta-hydroxysteroid dehydrogenase type 1
-
Homo sapiens
17beta-hydroxysteroid dehydrogenase type 2
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
additional information
-
value higher than 0.02, pH 7.4, 37°C Homo sapiens (2,4-dihydroxyphenyl)-phenylmethanone
additional information
-
value higher than 0.065, pH 7.4, 37°C Homo sapiens (2,4-dihydroxyphenyl)-phenylmethanone
0.0059
-
pH 7.4, 37°C Homo sapiens 4-methylbenzylidene camphor
0.006
-
pH 7.4, 37°C Homo sapiens 3-benzylidene camphor
0.0103
-
pH 7.4, 37°C Homo sapiens 2,2',4,4'-tetrahydroxybenzophenone
0.042
-
pH 7.4, 37°C Homo sapiens 2,2',4,4'-tetrahydroxybenzophenone
0.07
-
pH 7.4, 37°C Homo sapiens 4-methylbenzylidene camphor
0.072
-
pH 7.4, 37°C Homo sapiens 3-benzylidene camphor