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Literature summary for 1.1.1.62 extracted from

  • Al-Soud, Y.A.; Bey, E.; Oster, A.; Marchais-Oberwinkler, S.; Werth, R.; Kruchten, P.; Frotscher, M.; Hartmann, R.W.
    The role of the heterocycle in bis(hydroxyphenyl)triazoles for inhibition of 17beta-hydroxysteroid dehydrogenase (17beta-HSD) type 1 and type 2 (2009), Mol. Cell. Endocrinol., 301, 212-215.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
3,3'-(1-methyl-1H-1,2,4-triazole-3,5-diyl)diphenol
-
Homo sapiens
3,3'-(1-phenyl-1H-1,2,4-triazole-3,5-diyl)diphenol
-
Homo sapiens
3,3'-(1H-1,2,3-triazole-1,4-diyl)diphenol 17% inhibition at 0.001 mM Homo sapiens
3-[1-(4-hydroxyphenyl)-1H-1,2,3-triazol-4-yl]phenol
-
Homo sapiens
3-[3-(4-hydroxyphenyl)-1-methyl-1H-1,2,4-triazol-5-yl]phenol
-
Homo sapiens
3-[3-(4-hydroxyphenyl)-1-phenyl-1H-1,2,4-triazol-5-yl]phenol
-
Homo sapiens
3-[4-(4-hydroxyphenyl)-1H-1,2,3-triazol-1-yl]phenol
-
Homo sapiens
3-[5-(4-hydroxyphenyl)-1-methyl-1H-1,2,4-triazol-3-yl]phenol
-
Homo sapiens
3-[5-(4-hydroxyphenyl)-1-phenyl-1H-1,2,4-triazol-3-yl]phenol
-
Homo sapiens
additional information not inhibited by 3,3'-(1-methyl-1H-1,2,4-triazole-3,5-diyl)diphenol, 3-[5-(4-hydroxyphenyl)-1-methyl-1H-1,2,4-triazol-3-yl]phenol, 3-[3-(4-hydroxyphenyl)-1-methyl-1H-1,2,4-triazol-5-yl]phenol, 3,3'-(1-phenyl-1H-1,2,4-triazole-3,5-diyl)diphenol, 3-[5-(4-hydroxyphenyl)-1-phenyl-1H-1,2,4-triazol-3-yl]phenol, and 3-[3-(4-hydroxyphenyl)-1-phenyl-1H-1,2,4-triazol-5-yl]phenol Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
placenta
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
estradiol-17beta + NAD(P)+
-
Homo sapiens estrone + NAD(P)H + H+
-
ir
estrone + NADPH
-
Homo sapiens estradiol + NADP+ + H+
-
?
estrone + NADPH + H+
-
Homo sapiens estradiol + NADP+
-
?

Synonyms

Synonyms Comment Organism
(17beta-HSD) type 1
-
Homo sapiens
(17beta-HSD) type 2
-
Homo sapiens
17beta-HSD1
-
Homo sapiens
17beta-hydroxysteroid dehydrogenase
-
Homo sapiens
17beta-hydroxysteroid dehydrogenase type 1
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD(P)+
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00084
-
-
Homo sapiens 3-[1-(4-hydroxyphenyl)-1H-1,2,3-triazol-4-yl]phenol
0.00084
-
-
Homo sapiens 3-[4-(4-hydroxyphenyl)-1H-1,2,3-triazol-1-yl]phenol
0.00084
-
37°C, pH not specified in the publication Homo sapiens 3-[4-(4-hydroxyphenyl)-1H-1,2,3-triazol-1-yl]phenol
0.00132
-
-
Homo sapiens 3-[1-(4-hydroxyphenyl)-1H-1,2,3-triazol-4-yl]phenol
0.00132
-
37°C, pH not specified in the publication Homo sapiens 3-[1-(4-hydroxyphenyl)-1H-1,2,3-triazol-4-yl]phenol
0.017
-
-
Homo sapiens 3,3'-(1H-1,2,3-triazole-1,4-diyl)diphenol
0.017
-
37°C, pH not specified in the publication Homo sapiens 3,3'-(1H-1,2,3-triazole-1,4-diyl)diphenol
0.02
-
37°C, pH not specified in the publication Homo sapiens 3-[5-(4-hydroxyphenyl)-1-methyl-1H-1,2,4-triazol-3-yl]phenol
0.021
-
37°C, pH not specified in the publication Homo sapiens 3-[3-(4-hydroxyphenyl)-1-methyl-1H-1,2,4-triazol-5-yl]phenol
0.041
-
37°C, pH not specified in the publication Homo sapiens 3,3'-(1-phenyl-1H-1,2,4-triazole-3,5-diyl)diphenol
0.044
-
37°C, pH not specified in the publication Homo sapiens 3-[5-(4-hydroxyphenyl)-1-phenyl-1H-1,2,4-triazol-3-yl]phenol
40.88
-
37°C, pH not specified in the publication Homo sapiens 3-[1-(4-hydroxyphenyl)-1H-1,2,3-triazol-4-yl]phenol
46.94
-
37°C, pH not specified in the publication Homo sapiens 3-[4-(4-hydroxyphenyl)-1H-1,2,3-triazol-1-yl]phenol