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Literature summary for 1.1.1.62 extracted from

  • Saloniemi, T.; Lamminen, T.; Huhtinen, K.; Welsh, M.; Saunders, P.; Kujari, H.; Poutanen, M.
    Activation of androgens by hydroxysteroid (17beta) dehydrogenase 1 in vivo as a cause of prenatal masculinization and ovarian benign serous cystadenomas (2007), Mol. Endocrinol., 21, 2627-2636.
    View publication on PubMed

Application

Application Comment Organism
medicine disease iondications for HSD17B1 inhibitors in disorders in the female reproductive organs associated with enhanced androgen action, such as ovarian serous cystadenomas Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
transgenic mouse lines universally overexpressing human HSD17B1 are generated and characterized at fetal and adult ages Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
androstenedione + NAD(P)H + H+ Homo sapiens
-
testosterone + NADP+
-
?
estrone + NAD(P)H + H+ Homo sapiens
-
estradiol + NAD(P)+
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P14016
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
androstenedione + NAD(P)H + H+
-
Homo sapiens testosterone + NADP+
-
?
estrone + NAD(P)H + H+
-
Homo sapiens estradiol + NAD(P)+
-
?

Synonyms

Synonyms Comment Organism
HSD17B1
-
Homo sapiens