Application | Comment | Organism |
---|---|---|
medicine | 17beta-HSD1 is an attractive target for the treatment of mammary tumours | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-[1-(4-hydroxyphenyl)-1H-1,2,3-triazol-4-yl]-phenol | 17beta-HSD1; substrate: estradiol-17beta, 17beta-HSD2 | Homo sapiens | |
3-[3-(4-hydroxyphenyl)isoxazol-5-yl]-phenol | 17beta-HSD1; substrate: estradiol-17beta, 17beta-HSD2 | Homo sapiens | |
3-[4-(4-hydroxyphenyl)-1,3-oxazol-2-yl]-phenol | 17beta-HSD1 | Homo sapiens | |
3-[4-(4-hydroxyphenyl)-1,3-oxazol-2-yl]phenol | substrate: estradiol-17beta, 17beta-HSD2 | Homo sapiens | |
3-[4-(4-hydroxyphenyl)-1H-1,2,3-triazol-1-yl]-phenol | 17beta-HSD1; substrate: estradiol-17beta, 17beta-HSD2 | Homo sapiens | |
3-[5-(4-hydroxyphenyl)-1,3-oxazol-2-yl]-phenol | substrate: estradiol-17beta, 17beta-HSD2, very good selectivity, high cell permeability and medium CaCo-2 permeability; very good selectivity, high cell permeability and medium CaCo-2 permeability, 17beta-HSD1 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | 17beta-HSD1 | Homo sapiens | 5829 | - |
microsome | 17beta-HSD2 | Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Homo sapiens | P14061 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
placenta | 17beta-HSD1 | Homo sapiens | - |
placenta | 17beta-HSD2 | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
estradiol-17beta + NAD+ | 17beta-HSD2 | Homo sapiens | estrone + NADH + H+ | - |
? | |
estrone + NADH + H+ | 17beta-HSD1 | Homo sapiens | estradiol-17beta + NAD+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
17beta-HSD1 | - |
Homo sapiens |
17beta-HSD2 | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00025 | - |
substrate: estradiol-17beta, 17beta-HSD2 | Homo sapiens | 3-[4-(4-hydroxyphenyl)-1,3-oxazol-2-yl]-phenol | |
0.00027 | - |
substrate: estradiol-17beta, 17beta-HSD2 | Homo sapiens | 3-[3-(4-hydroxyphenyl)isoxazol-5-yl]-phenol | |
0.00031 | - |
substrate: estrone, 17beta-HSD1 | Homo sapiens | 3-[5-(4-hydroxyphenyl)-1,3-oxazol-2-yl]-phenol | |
0.00084 | - |
substrate: estrone, 17beta-HSD1 | Homo sapiens | 3-[4-(4-hydroxyphenyl)-1H-1,2,3-triazol-1-yl]-phenol | |
0.00132 | - |
substrate: estrone, 17beta-HSD1 | Homo sapiens | 3-[1-(4-hydroxyphenyl)-1H-1,2,3-triazol-4-yl]-phenol | |
0.00161 | - |
substrate: estrone, 17beta-HSD1 | Homo sapiens | 3-[3-(4-hydroxyphenyl)isoxazol-5-yl]-phenol | |
0.00185 | - |
substrate: estrone, 17beta-HSD1 | Homo sapiens | 3-[4-(4-hydroxyphenyl)-1,3-oxazol-2-yl]-phenol | |
0.00728 | - |
substrate: estradiol-17beta, 17beta-HSD2 | Homo sapiens | 3-[4-(4-hydroxyphenyl)-1H-1,2,3-triazol-1-yl]-phenol | |
0.00812 | - |
substrate: estradiol-17beta, 17beta-HSD2 | Homo sapiens | 3-[1-(4-hydroxyphenyl)-1H-1,2,3-triazol-4-yl]-phenol | |
0.0175 | - |
substrate: estrone, 17beta-HSD2 | Homo sapiens | 3-[5-(4-hydroxyphenyl)-1,3-oxazol-2-yl]-phenol |