Cloned (Comment) | Organism |
---|---|
expression of AKR1C3 in Eschericha coli | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-methylcinnamic acid | IC50: 0.0064 mM | Homo sapiens | |
3,4,5-trimethoxycinnamic acid | IC50: 0.049 mM | Homo sapiens | |
3-coumaric acid | 34% inhibition at 0.05 mM | Homo sapiens | |
3-cyclohexylpropanoic acid | weak inhibition, IC50: 0.1 mM, above | Homo sapiens | |
3-trifluoromethylcinnamic acid | IC50: 0.043 mM | Homo sapiens | |
caffeic acid | 18% inhibition at 0.05 mM | Homo sapiens | |
Cinnamic acid | IC50: 0.050 mM | Homo sapiens | |
coumarin-3-carboxylic acid | 30% inhibition at 0.05 mM | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
estrone + NADPH | Homo sapiens | convertion of the weak androgen estrone into the potent estrogen 17beta-estradiol | 17beta-estradiol + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
9,10-phenanthrenequinone + NADPH | - |
Homo sapiens | ? | - |
? | |
estrone + NADPH | - |
Homo sapiens | 17beta-estradiol + NADP+ | - |
? | |
estrone + NADPH | convertion of the weak androgen estrone into the potent estrogen 17beta-estradiol | Homo sapiens | 17beta-estradiol + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
17beta-HSD type 5 | - |
Homo sapiens |
17beta-hydroxysteroid dehydrogenase type 5 | - |
Homo sapiens |
AKR1C3 | - |
Homo sapiens |
More | the enzyme belongs to the aldo-keto reductase family | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.5 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0064 | - |
IC50: 0.0064 mM | Homo sapiens | 2-methylcinnamic acid | |
0.043 | - |
IC50: 0.043 mM | Homo sapiens | 3-trifluoromethylcinnamic acid | |
0.049 | - |
IC50: 0.049 mM | Homo sapiens | 3,4,5-trimethoxycinnamic acid | |
0.05 | - |
IC50: 0.050 mM | Homo sapiens | Cinnamic acid | |
0.1 | - |
weak inhibition, IC50: 0.1 mM, above | Homo sapiens | 3-cyclohexylpropanoic acid |