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Literature summary for 1.1.1.51 extracted from
- The UV-filter benzophenone-1 inhibits 17beta-hydroxysteroid dehydrogenase type 3: Virtual screening as a strategy to identify potential endocrine disrupting chemicals (2010), Biochem. Pharmacol., 79, 1189-1199.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in HEK-293 cells by transient transfection | Mus musculus |
| expressed in HEK-293 cells by transient transfection | Rattus norvegicus |
| expressed in HEK-293 cells by transient transfection | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (2,4-dihydroxyphenyl)-phenylmethanone | remaining 17beta HSD3 activity: 1.1% | Homo sapiens |  |
| (2,4-dihydroxyphenyl)-phenylmethanone | (2,4-dihydroxyphenyl)-phenylmethanone leads to inhibition of testosterone synthesis in freshly isolated mouse and rat testis tissue | Mus musculus | |
| (2,4-dihydroxyphenyl)-phenylmethanone | (2,4-dihydroxyphenyl)-phenylmethanone leads to inhibition of testosterone synthesis in freshly isolated mouse and rat testis tissue | Rattus norvegicus | |
| 12-acetyl-11,12-dihydro-2-(trifluoromethyl)-6H-dibenzo(b,f)(1,4)thiazocine | - |
Homo sapiens | |
| 12-acetyl-11,12-dihydro-6H-dibenzo(b,f)(1,4)thiazocine | - |
Homo sapiens | |
| 2,2',4,4'-tetrahydroxybenzophenone | remaining 17beta HSD3 activity: 47% | Homo sapiens | |
| 2,5-dioxo-3-(2-propyn-1-yl)-3-pyrrolidinecarboxylic acid 2,3,3-triphenyl-2-propen-1-yl-ester | - |
Homo sapiens | |
| 2-((3-chloro-4-hydroxybenzoyl)amino)-N-(2-(2-methoxyphenyl)ethyl)-5-phenoxy-benzamide | - |
Homo sapiens | |
| 2-(5-acetyl-2-chloro-5,6,11,12-tetrahydrodibenzo(b,f)azocin-8-yl)-benzoic acid methyl ester | - |
Homo sapiens | |
| 3-benzylidene camphor | remaining 17beta HSD3 activity: 56% | Homo sapiens | |
| 3alpha-butyl-3-hydroxy-5alpha-androstan-17-one | - |
Homo sapiens | |
| 4-methylbenzylidene camphor | remaining 17beta HSD3 activity: 33% | Homo sapiens | |
| 5-acetyl-2-chloro-5,6-dihydro-dibenzo(b,f)azocine | - |
Homo sapiens | |
| 5-acetyl-5,6,11,12-tetrahydro-dibenzo(b,f)(1,4)diazocine | - |
Homo sapiens | |
| androsterone | - |
Homo sapiens | |
| N-(((3,5)-3-hydroxy-17-oxoandrostan-3-yl)methyl)-N-(tricyclo(3.3.1.13.7)dec-2-ylmethyl)butanamide | - |
Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P37058 | - |
- |
| Mus musculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| testis | - |
Mus musculus | - |
| testis | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-androstene-3,17-dione + NADPH + H+ | - |
Homo sapiens | testosterone + NADP+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 17beta-HSD3 | - |
Mus musculus |
| 17beta-HSD3 | - |
Rattus norvegicus |
| 17beta-HSD3 | - |
Homo sapiens |
| 17beta-hydroxysteroid dehydrogenase type 3 | - |
Mus musculus |
| 17beta-hydroxysteroid dehydrogenase type 3 | - |
Rattus norvegicus |
| 17beta-hydroxysteroid dehydrogenase type 3 | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Mus musculus |
| 37 | - |
assay at | Rattus norvegicus |
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Mus musculus |
| 7.4 | - |
assay at | Rattus norvegicus |
| 7.4 | - |
assay at | Homo sapiens |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.00000002 | - |
pH and temperature not specified in the publication | Homo sapiens | 2-(5-acetyl-2-chloro-5,6,11,12-tetrahydrodibenzo(b,f)azocin-8-yl)-benzoic acid methyl ester | |
| 0.000035 | - |
pH and temperature not specified in the publication | Homo sapiens | N-(((3,5)-3-hydroxy-17-oxoandrostan-3-yl)methyl)-N-(tricyclo(3.3.1.13.7)dec-2-ylmethyl)butanamide | |
| 0.00006 | - |
pH and temperature not specified in the publication | Homo sapiens | 2-((3-chloro-4-hydroxybenzoyl)amino)-N-(2-(2-methoxyphenyl)ethyl)-5-phenoxy-benzamide | |
| 0.000116 | - |
pH and temperature not specified in the publication | Homo sapiens | 3alpha-butyl-3-hydroxy-5alpha-androstan-17-one | |
| 0.000182 | - |
pH and temperature not specified in the publication | Homo sapiens | androsterone | |
| 0.00024 | - |
pH and temperature not specified in the publication | Homo sapiens | 5-acetyl-2-chloro-5,6-dihydro-dibenzo(b,f)azocine | |
| 0.0004 | - |
pH and temperature not specified in the publication | Homo sapiens | 12-acetyl-11,12-dihydro-6H-dibenzo(b,f)(1,4)thiazocine | |
| 0.001 | - |
pH 7.4, 37°C | Homo sapiens | (2,4-dihydroxyphenyl)-phenylmethanone | |
| 0.00281 | - |
pH and temperature not specified in the publication | Homo sapiens | 12-acetyl-11,12-dihydro-2-(trifluoromethyl)-6H-dibenzo(b,f)(1,4)thiazocine | |
| 0.00474 | - |
pH and temperature not specified in the publication | Homo sapiens | 5-acetyl-5,6,11,12-tetrahydro-dibenzo(b,f)(1,4)diazocine | |
| 0.00915 | - |
pH and temperature not specified in the publication | Homo sapiens | 2,5-dioxo-3-(2-propyn-1-yl)-3-pyrrolidinecarboxylic acid 2,3,3-triphenyl-2-propen-1-yl-ester | |
| 0.0107 | - |
pH 7.4, 37°C | Homo sapiens | 4-methylbenzylidene camphor | |
| 0.0181 | - |
pH 7.4, 37°C | Homo sapiens | 2,2',4,4'-tetrahydroxybenzophenone | |
| 0.033 | - |
pH 7.4, 37°C | Homo sapiens | 3-benzylidene camphor | |
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