Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
pregn-4-en-3,20-dione + NADPH + H+ | Rattus norvegicus | progesterone | 3alpha-hydroxypregn-4-en-20-one + NADP+ | allopregnanolone | r | |
pregn-4-en-3,20-dione + NADPH + H+ | Rattus norvegicus Sprague-Dawley | progesterone | 3alpha-hydroxypregn-4-en-20-one + NADP+ | allopregnanolone | r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | P23457 | - |
- |
Rattus norvegicus Sprague-Dawley | P23457 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | from male rats | Rattus norvegicus | - |
striatum | - |
Rattus norvegicus | - |
substantia nigra | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
pregn-4-en-3,20-dione + NADPH + H+ | progesterone | Rattus norvegicus | 3alpha-hydroxypregn-4-en-20-one + NADP+ | allopregnanolone | r | |
pregn-4-en-3,20-dione + NADPH + H+ | progesterone | Rattus norvegicus Sprague-Dawley | 3alpha-hydroxypregn-4-en-20-one + NADP+ | allopregnanolone | r |
Synonyms | Comment | Organism |
---|---|---|
3alpha-HSOR | - |
Rattus norvegicus |
3alpha-hydroxysteroid oxidoreductase | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.5 | - |
assay at | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Rattus norvegicus | |
NADPH | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | the 3alpha-HSOR mRNA ipsilateral expression of progesterone-treated hemiparkinsonian animals is significantly augmented compared to sham and hemiparkinsonian rats. On the other hand, 3alpha-HSOR mRNA expression is no different among groups when substantia nigra samples contralateral to lesion are considered | additional information |
General Information | Comment | Organism |
---|---|---|
additional information | effect of progesterone in lesions, caused by neurotoxic 6-hydroxydopamine hydrobromide, on the contralateral turning behavior, overview | Rattus norvegicus |