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Literature summary for 1.1.1.49 extracted from

  • Wakao, S.; Andre, C.; Benning, C.
    Functional analyses of cytosolic glucose-6-phosphate dehydrogenases and their contribution to seed oil accumulation in arabidopsis (2008), Plant Physiol., 146, 277-288.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
sucrose in wild-type seedlings G6PD5 and G6PD6 show small (1.7- and 2fold, respectively) but significant induction by sucrose Arabidopsis thaliana

Application

Application Comment Organism
additional information loss of cytosolic G6PDH activity affects the metabolism of developing seeds by increasing carbon substrates for synthesis of storage compounds rather than by decreasing the NADPH supply specifically for fatty acid synthesis Arabidopsis thaliana

Cloned(Commentary)

Cloned (Comment) Organism
transient expression of the G6PD5 and G6PD6 fused to a GFP gene, cloned into the SpeI site of pCAMBIA1302. T-DNA insertion lines transformed with cosmid clones containing the regions of G6PD5 and G6PD6 isolated from a genomic cosmid (pBIC20) library Arabidopsis thaliana

Protein Variants

Protein Variants Comment Organism
additional information activities of the cytosolic isoforms G6PD5 and G6PD6 are reciprocally increased in single mutants with no increase of their respective transcript levels. Seeds of the double mutant but not of the single mutants have higher oil content and increased weight compared to those of the wild-type, with no alteration in the carbon to nitrogen ratio or fatty acid composition. Total G6PDH activity is reduced only in the double mutant Arabidopsis thaliana

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol G6PD5 and G6PD6 Arabidopsis thaliana 5829
-
plastid
-
Arabidopsis thaliana 9536
-

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
leaf
-
Arabidopsis thaliana
-
seed
-
Arabidopsis thaliana
-
seedling
-
Arabidopsis thaliana
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information G6PDH plays a role in supplying NADPH for oil accumulation in developing seeds in which photosynthesis may be light limited Arabidopsis thaliana ?
-
?

Synonyms

Synonyms Comment Organism
G6PD5
-
Arabidopsis thaliana
G6PD6
-
Arabidopsis thaliana
G6PDH
-
Arabidopsis thaliana

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Arabidopsis thaliana