Literature summary for 1.1.1.49 extracted from

Zhang, Z.; Apse, K.; Pang, J.; Stanton, R.C.
High glucose inhibits glucose-6-phosphate dehydrogenase via cAMP in aortic endothelial cells (2000), J. Biol. Chem., 275, 40042-40047.

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Inhibitors

Inhibitors	Comment	Organism	Structure
glucose	at concentration above 10 mM	Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
D-glucose 6-phosphate + H2O + NADP+	Bos taurus	-	D-gluconate 6-phosphate + NADPH + H+	-	r

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	-	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH + H+	physiological regulating function is discussed	Bos taurus	a

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
D-glucose 6-phosphate + H2O + NADP+	-	Bos taurus	D-gluconate 6-phosphate + NADPH + H+	-	r

Cofactor

Cofactor	Comment	Organism	Structure
NADP+	-	Bos taurus

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Release 2023.1 (January 2023)