Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,8-dihydroxy-3-methoxy-6-methyl-anthraquinone | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
6-phospho-D-gluconate + NADP+ | Homo sapiens | - |
D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
212LN cell | - |
Homo sapiens | - |
H-1299 cell | - |
Homo sapiens | - |
H-157 cell | - |
Homo sapiens | - |
H-322 cell | - |
Homo sapiens | - |
HaCaT cell | - |
Homo sapiens | - |
K-562 cell | - |
Homo sapiens | - |
MDA-MB-231 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
6-phospho-D-gluconate + NADP+ | - |
Homo sapiens | D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
6-phosphogluconate dehydrogenase | - |
Homo sapiens |
6PGD | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | dependent on | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme suppression decreases lipogenesis and RNA biosynthesis and elevates reactive oxygen species levels in cancer cells, attenuating cell proliferation and tumor growth | Homo sapiens |
metabolism | enzyme-mediated production of D-ribulose 5-phosphate inhibits adenine monophosphate-activated protein kinase activation by disrupting the active tumor suppressor liver kinase B1 complex, thereby activating acetyl-CoA carboxylase 1 and lipogenesis | Homo sapiens |
physiological function | the enzyme is important for oxidative triphosphate and lipogenesis, as well as proliferative and tumor growth potential of cancer cells | Homo sapiens |