Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2R)-(2-hydroxy-3-phosphonooxypropane-1-sulfinyl)acetic acid | compound shows in vitro antiparasitic activity | Leishmania donovani | |
(2R)-(2-hydroxy-3-phosphonooxypropane-1-sulfinyl)acetic acid | - |
Ovis aries | |
(2R)-(2-hydroxy-3-phosphonooxypropane-1-sulfinyl)acetic acid | compound shows in vitro antiparasitic activity | Plasmodium falciparum | |
(2R)-(2-hydroxy-3-phosphonooxypropane-1-sulfinyl)acetic acid | compound shows in vitro antiparasitic activity | Trypanosoma brucei | |
(2R)-(2-hydroxy-3-phosphonooxypropane-1-sulfinyl)acetic acid | compound shows in vitro antiparasitic activity | Trypanosoma cruzi | |
(2R)-[3-(bis(benzyloxy)phosphoryloxy)-2-(tetrahydropyran-2-yloxy)propane-1-sulfinyl]acetic acid | compound shows in vitro antiparasitic activity | Plasmodium falciparum | |
(2R)-[3-(bis(benzyloxy)phosphoryloxy)-2-(tetrahydropyran-2-yloxy)propane-1-sulfinyl]acetic acid | compound shows in vitro antiparasitic activity | Trypanosoma brucei | |
(2R)-[3-(bis(benzyloxy)phosphoryloxy)-2-(tetrahydropyran-2-yloxy)propane-1-sulfinyl]acetic acid | compound shows in vitro antiparasitic activity | Trypanosoma cruzi | |
(2R,3R)-2,3,4,N-tetrahydroxybutyramide | compound shows in vitro antiparasitic activity | Leishmania donovani | |
(2R,3R)-2,3,4,N-tetrahydroxybutyramide | compound shows in vitro antiparasitic activity | Plasmodium falciparum | |
(2R,3R)-2,3,4,N-tetrahydroxybutyramide | compound shows in vitro antiparasitic activity | Trypanosoma brucei | |
(2R,3R)-2,3,4,N-tetrahydroxybutyramide | compound shows in vitro antiparasitic activity | Trypanosoma cruzi | |
(3aR,6aR)-2,2-dimethyldihydrofuro[3,4-d][1,3]dioxol-4-one | compound shows in vitro antiparasitic activity | Leishmania donovani | |
(3aR,6aR)-2,2-dimethyldihydrofuro[3,4-d][1,3]dioxol-4-one | compound shows in vitro antiparasitic activity | Plasmodium falciparum | |
(3aR,6aR)-2,2-dimethyldihydrofuro[3,4-d][1,3]dioxol-4-one | compound shows in vitro antiparasitic activity | Trypanosoma brucei | |
(3aR,6aR)-2,2-dimethyldihydrofuro[3,4-d][1,3]dioxol-4-one | compound shows in vitro antiparasitic activity | Trypanosoma cruzi | |
(3R,4R)-3,4-di(tetrahydro-2H-pyranyloxy)tetrahydro-2-furanone | compound shows in vitro antiparasitic activity | Leishmania donovani | |
(3R,4R)-3,4-di(tetrahydro-2H-pyranyloxy)tetrahydro-2-furanone | compound shows in vitro antiparasitic activity | Plasmodium falciparum | |
(3R,4R)-3,4-di(tetrahydro-2H-pyranyloxy)tetrahydro-2-furanone | compound shows in vitro antiparasitic activity | Trypanosoma brucei | |
(3R,4R)-3,4-di(tetrahydro-2H-pyranyloxy)tetrahydro-2-furanone | compound shows in vitro antiparasitic activity | Trypanosoma cruzi | |
(4R,5R)-5-hydroxymethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid benzyloxyamide | compound shows in vitro antiparasitic activity | Leishmania donovani | |
(4R,5R)-5-hydroxymethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid benzyloxyamide | compound shows in vitro antiparasitic activity | Plasmodium falciparum | |
(4R,5R)-5-hydroxymethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid benzyloxyamide | compound shows in vitro antiparasitic activity | Trypanosoma brucei | |
(4R,5R)-5-hydroxymethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid benzyloxyamide | compound shows in vitro antiparasitic activity | Trypanosoma cruzi | |
2-deoxy-6-phosphono-D-gluconate | compound shows in vitro antiparasitic activity | Leishmania donovani | |
2-deoxy-6-phosphono-D-gluconate | - |
Ovis aries | |
2-deoxy-6-phosphono-D-gluconate | compound shows in vitro antiparasitic activity | Plasmodium falciparum | |
2-deoxy-6-phosphono-D-gluconate | compound shows in vitro antiparasitic activity | Trypanosoma brucei | |
2-deoxy-6-phosphono-D-gluconate | compound shows in vitro antiparasitic activity | Trypanosoma cruzi | |
4,N-dihydroxy(2R,3R)-2,3-bis(tetrahydropyran-2-yloxy)butyramide | compound shows in vitro antiparasitic activity | Leishmania donovani | |
4,N-dihydroxy(2R,3R)-2,3-bis(tetrahydropyran-2-yloxy)butyramide | compound shows in vitro antiparasitic activity | Plasmodium falciparum | |
4,N-dihydroxy(2R,3R)-2,3-bis(tetrahydropyran-2-yloxy)butyramide | compound shows in vitro antiparasitic activity | Trypanosoma brucei | |
4,N-dihydroxy(2R,3R)-2,3-bis(tetrahydropyran-2-yloxy)butyramide | compound shows in vitro antiparasitic activity | Trypanosoma cruzi | |
4-phospho-D-erythronamide | compound shows in vitro antiparasitic activity | Leishmania donovani | |
4-phospho-D-erythronamide | - |
Ovis aries | |
4-phospho-D-erythronamide | compound shows in vitro antiparasitic activity | Plasmodium falciparum | |
4-phospho-D-erythronamide | compound shows in vitro antiparasitic activity | Trypanosoma brucei | |
4-phospho-D-erythronamide | compound shows in vitro antiparasitic activity | Trypanosoma cruzi | |
4-phospho-D-erythronate | compound shows in vitro antiparasitic activity | Leishmania donovani | |
4-phospho-D-erythronate | - |
Ovis aries | |
4-phospho-D-erythronate | compound shows in vitro antiparasitic activity | Plasmodium falciparum | |
4-phospho-D-erythronate | compound shows in vitro antiparasitic activity | Trypanosoma brucei | |
4-phospho-D-erythronate | compound shows in vitro antiparasitic activity | Trypanosoma cruzi | |
4-phospho-D-erythronohydroxamic acid | compound shows low in vitro antiparasitic activity | Leishmania donovani | |
4-phospho-D-erythronohydroxamic acid | - |
Ovis aries | |
4-phospho-D-erythronohydroxamic acid | compound shows low in vitro antiparasitic activity | Plasmodium falciparum | |
4-phospho-D-erythronohydroxamic acid | compound shows low in vitro antiparasitic activity | Trypanosoma brucei | |
4-phospho-D-erythronohydroxamic acid | compound shows low in vitro antiparasitic activity | Trypanosoma cruzi | |
acetic acid (1R,2R)-2-acetoxy-1-(acetylbenzyloxyaminocarbonyl)-3-(bis(benzyloxy)phosphoryloxy)propyl ester | compound shows in vitro antiparasitic activity | Leishmania donovani | |
acetic acid (1R,2R)-2-acetoxy-1-(acetylbenzyloxyaminocarbonyl)-3-(bis(benzyloxy)phosphoryloxy)propyl ester | - |
Ovis aries | |
acetic acid (1R,2R)-2-acetoxy-1-(acetylbenzyloxyaminocarbonyl)-3-(bis(benzyloxy)phosphoryloxy)propyl ester | compound shows in vitro antiparasitic activity | Plasmodium falciparum | |
acetic acid (1R,2R)-2-acetoxy-1-(acetylbenzyloxyaminocarbonyl)-3-(bis(benzyloxy)phosphoryloxy)propyl ester | compound shows in vitro antiparasitic activity | Trypanosoma brucei | |
acetic acid (1R,2R)-2-acetoxy-1-(acetylbenzyloxyaminocarbonyl)-3-(bis(benzyloxy)phosphoryloxy)propyl ester | compound shows in vitro antiparasitic activity | Trypanosoma cruzi | |
acetic acid (1R,2R)-2-acetoxy-1-benzyloxycarbamoyl-3-(bis(benzyloxy)phosphoryloxy)propyl ester | compound shows in vitro antiparasitic activity | Leishmania donovani | |
acetic acid (1R,2R)-2-acetoxy-1-benzyloxycarbamoyl-3-(bis(benzyloxy)phosphoryloxy)propyl ester | compound shows in vitro antiparasitic activity | Plasmodium falciparum | |
acetic acid (1R,2R)-2-acetoxy-1-benzyloxycarbamoyl-3-(bis(benzyloxy)phosphoryloxy)propyl ester | compound shows in vitro antiparasitic activity | Trypanosoma brucei | |
acetic acid (1R,2R)-2-acetoxy-1-benzyloxycarbamoyl-3-(bis(benzyloxy)phosphoryloxy)propyl ester | compound shows in vitro antiparasitic activity | Trypanosoma cruzi | |
acetic acid (2R,1R)-2-acetoxy-1-hydroxycarbamoyl-3-phosphonooxypropyl ester | - |
Ovis aries | |
acetic acid (2R,1R)-2-acetoxy-1-hydroxycarbamoyl-3-phosphonooxypropyl ester | compound shows in vitro antiparasitic activity | Plasmodium falciparum | |
acetic acid (2R,1R)-2-acetoxy-1-hydroxycarbamoyl-3-phosphonooxypropyl ester | compound shows in vitro antiparasitic activity | Trypanosoma brucei | |
acetic acid (2R,1R)-2-acetoxy-1-hydroxycarbamoyl-3-phosphonooxypropyl ester | compound shows in vitro antiparasitic activity | Trypanosoma cruzi | |
additional information | IC50 for antiparasitic activity of inhibitors, overview | Leishmania donovani | |
additional information | no inhibition by [3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid, [(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propane-1-sulfinyl]acetic acid benzyl ester, (2R)-[3-(bis(benzyloxy)phosphoryloxy)-2-(tetrahydropyran-2-yloxy)propane-1-sulfinyl]acetic acid, and acetic acid (1R,2R)-2-acetoxy-1-benzyloxycarbamoyl-3-(bis(benzyloxy)phosphoryloxy)propyl ester | Ovis aries | |
additional information | IC50 for antiparasitic activity of inhibitors, overview | Plasmodium falciparum | |
additional information | IC50 values for antiparasitic activity of inhibitors, overview | Trypanosoma brucei | |
additional information | IC50 values for antiparasitic activity of inhibitors, overview | Trypanosoma cruzi | |
phosphoric acid dibenzyl ester (2R,3R)-3-benzyloxycarbamoyl-2,3-dihydroxypropyl ester | compound shows in vitro antiparasitic activity | Leishmania donovani | |
phosphoric acid dibenzyl ester (2R,3R)-3-benzyloxycarbamoyl-2,3-dihydroxypropyl ester | compound shows in vitro antiparasitic activity | Plasmodium falciparum | |
phosphoric acid dibenzyl ester (2R,3R)-3-benzyloxycarbamoyl-2,3-dihydroxypropyl ester | compound shows in vitro antiparasitic activity | Trypanosoma brucei | |
phosphoric acid dibenzyl ester (2R,3R)-3-benzyloxycarbamoyl-2,3-dihydroxypropyl ester | compound shows in vitro antiparasitic activity | Trypanosoma cruzi | |
phosphoric acid dibenzyl ester (4R,5R)-5-benzyloxycarbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester | compound shows in vitro antiparasitic activity | Leishmania donovani | |
phosphoric acid dibenzyl ester (4R,5R)-5-benzyloxycarbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester | compound shows in vitro antiparasitic activity | Plasmodium falciparum | |
phosphoric acid dibenzyl ester (4R,5R)-5-benzyloxycarbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester | compound shows in vitro antiparasitic activity | Trypanosoma brucei | |
phosphoric acid dibenzyl ester (4R,5R)-5-benzyloxycarbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester | compound shows in vitro antiparasitic activity | Trypanosoma cruzi | |
phosphoric acid mono-[(4R,5R)-5-carbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl] ester | - |
Ovis aries | |
phosphoric acid mono-[(4R,5R)-5-carbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl] ester | compound shows in vitro antiparasitic activity | Plasmodium falciparum | |
phosphoric acid mono-[(4R,5R)-5-carbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl] ester | compound shows in vitro antiparasitic activity | Trypanosoma brucei | |
phosphoric acid mono-[(4R,5R)-5-carbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl] ester | compound shows in vitro antiparasitic activity | Trypanosoma cruzi | |
phosphoric acid mono-[(5R,4R)-5-hydroxycarbamoyl-2,2-dimethyl[1,3]dioxolan-4-ylmethyl] ester | compound shows low in vitro antiparasitic activity | Leishmania donovani | |
phosphoric acid mono-[(5R,4R)-5-hydroxycarbamoyl-2,2-dimethyl[1,3]dioxolan-4-ylmethyl] ester | - |
Ovis aries | |
phosphoric acid mono-[(5R,4R)-5-hydroxycarbamoyl-2,2-dimethyl[1,3]dioxolan-4-ylmethyl] ester | compound shows low in vitro antiparasitic activity | Plasmodium falciparum | |
phosphoric acid mono-[(5R,4R)-5-hydroxycarbamoyl-2,2-dimethyl[1,3]dioxolan-4-ylmethyl] ester | compound shows low in vitro antiparasitic activity | Trypanosoma brucei | |
phosphoric acid mono-[(5R,4R)-5-hydroxycarbamoyl-2,2-dimethyl[1,3]dioxolan-4-ylmethyl] ester | compound shows low in vitro antiparasitic activity | Trypanosoma cruzi | |
[(2R)-2,3-dihydroxypropylsulfanyl]acetic acid benzyl ester | compound shows in vitro antiparasitic activity | Leishmania donovani | |
[(2R)-2,3-dihydroxypropylsulfanyl]acetic acid benzyl ester | compound shows in vitro antiparasitic activity | Plasmodium falciparum | |
[(2R)-2,3-dihydroxypropylsulfanyl]acetic acid benzyl ester | compound shows in vitro antiparasitic activity | Trypanosoma brucei | |
[(2R)-2,3-dihydroxypropylsulfanyl]acetic acid benzyl ester | compound shows in vitro antiparasitic activity | Trypanosoma cruzi | |
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propane-1-sulfinyl]acetic acid benzyl ester | compound shows in vitro antiparasitic activity | Leishmania donovani | |
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propane-1-sulfinyl]acetic acid benzyl ester | compound shows in vitro antiparasitic activity | Plasmodium falciparum | |
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propane-1-sulfinyl]acetic acid benzyl ester | compound shows in vitro antiparasitic activity | Trypanosoma brucei | |
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propane-1-sulfinyl]acetic acid benzyl ester | compound shows in vitro antiparasitic activity | Trypanosoma cruzi | |
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propylsulfanyl]acetic acid | compound shows in vitro antiparasitic activity | Leishmania donovani | |
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propylsulfanyl]acetic acid | compound shows in vitro antiparasitic activity | Plasmodium falciparum | |
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propylsulfanyl]acetic acid | compound shows in vitro antiparasitic activity | Trypanosoma brucei | |
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propylsulfanyl]acetic acid | compound shows in vitro antiparasitic activity | Trypanosoma cruzi | |
[(2R)-2-acetoxy-3-phosphonooxypropane-1-sulfinyl]acetic acid | - |
Ovis aries | |
[(2R)-2-acetoxy-3-phosphonooxypropane-1-sulfinyl]acetic acid | compound shows in vitro antiparasitic activity | Plasmodium falciparum | |
[(2R)-2-acetoxy-3-phosphonooxypropane-1-sulfinyl]acetic acid | compound shows in vitro antiparasitic activity | Trypanosoma brucei | |
[(2R)-2-acetoxy-3-phosphonooxypropane-1-sulfinyl]acetic acid | compound shows in vitro antiparasitic activity | Trypanosoma cruzi | |
[(4R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethylsulfanyl]acetic acid benzyl ester | compound shows low in vitro antiparasitic activity | Leishmania donovani | |
[(4R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethylsulfanyl]acetic acid benzyl ester | compound shows low in vitro antiparasitic activity | Plasmodium falciparum | |
[(4R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethylsulfanyl]acetic acid benzyl ester | compound shows low in vitro antiparasitic activity | Trypanosoma brucei | |
[(4R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethylsulfanyl]acetic acid benzyl ester | compound shows low in vitro antiparasitic activity | Trypanosoma cruzi | |
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid | compound shows in vitro antiparasitic activity | Leishmania donovani | |
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid | compound shows in vitro antiparasitic activity | Plasmodium falciparum | |
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid | compound shows in vitro antiparasitic activity | Trypanosoma brucei | |
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid | compound shows in vitro antiparasitic activity | Trypanosoma cruzi | |
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid benzyl ester | compound shows in vitro antiparasitic activity | Leishmania donovani | |
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid benzyl ester | compound shows in vitro antiparasitic activity | Plasmodium falciparum | |
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid benzyl ester | compound shows in vitro antiparasitic activity | Trypanosoma brucei | |
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid benzyl ester | compound shows in vitro antiparasitic activity | Trypanosoma cruzi |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0035 | - |
6-phosphono-D-gluconate | pH 7.5, 20°C | Trypanosoma brucei | |
0.016 | - |
6-phosphono-D-gluconate | pH 7.5, 20°C | Ovis aries |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Leishmania donovani | - |
- |
- |
Ovis aries | - |
- |
- |
Plasmodium falciparum | - |
- |
- |
Trypanosoma brucei | - |
- |
- |
Trypanosoma cruzi | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Ovis aries | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3-keto-6-phospho-D-gluconate | via 1,2-enediol intermediate | Ovis aries | D-ribulose 5-phosphate + CO2 | - |
? | |
3-keto-6-phospho-D-gluconate | via 1,2-enediol intermediate | Trypanosoma brucei | D-ribulose 5-phosphate + CO2 | - |
? | |
3-keto-6-phospho-D-gluconate | via 1,2-enediol intermediate | Leishmania donovani | D-ribulose 5-phosphate + CO2 | - |
? | |
3-keto-6-phospho-D-gluconate | via 1,2-enediol intermediate | Trypanosoma cruzi | D-ribulose 5-phosphate + CO2 | - |
? | |
3-keto-6-phospho-D-gluconate | via 1,2-enediol intermediate | Plasmodium falciparum | D-ribulose 5-phosphate + CO2 | - |
? | |
6-phospho-D-gluconate + NADP+ | overall reaction | Ovis aries | D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
? | |
6-phospho-D-gluconate + NADP+ | overall reaction | Trypanosoma brucei | D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
? | |
6-phospho-D-gluconate + NADP+ | overall reaction | Leishmania donovani | D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
? | |
6-phospho-D-gluconate + NADP+ | overall reaction | Trypanosoma cruzi | D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
? | |
6-phospho-D-gluconate + NADP+ | overall reaction | Plasmodium falciparum | D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
? | |
6-phospho-D-gluconate + NADP+ | - |
Ovis aries | 3-keto-6-phospho-D-gluconate + NADPH + H+ | - |
? | |
6-phospho-D-gluconate + NADP+ | - |
Trypanosoma brucei | 3-keto-6-phospho-D-gluconate + NADPH + H+ | - |
? | |
6-phospho-D-gluconate + NADP+ | - |
Leishmania donovani | 3-keto-6-phospho-D-gluconate + NADPH + H+ | - |
? | |
6-phospho-D-gluconate + NADP+ | - |
Trypanosoma cruzi | 3-keto-6-phospho-D-gluconate + NADPH + H+ | - |
? | |
6-phospho-D-gluconate + NADP+ | - |
Plasmodium falciparum | 3-keto-6-phospho-D-gluconate + NADPH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
6-phosphogluconate dehydrogenase | - |
Ovis aries |
6-phosphogluconate dehydrogenase | - |
Trypanosoma brucei |
6-phosphogluconate dehydrogenase | - |
Leishmania donovani |
6-phosphogluconate dehydrogenase | - |
Trypanosoma cruzi |
6-phosphogluconate dehydrogenase | - |
Plasmodium falciparum |
6PGDH | - |
Ovis aries |
6PGDH | - |
Trypanosoma brucei |
6PGDH | - |
Leishmania donovani |
6PGDH | - |
Trypanosoma cruzi |
6PGDH | - |
Plasmodium falciparum |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
20 | - |
assay at | Ovis aries |
20 | - |
assay at | Trypanosoma brucei |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Ovis aries |
7.5 | - |
assay at | Trypanosoma brucei |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Ovis aries | |
NADP+ | - |
Trypanosoma brucei | |
NADP+ | - |
Leishmania donovani | |
NADP+ | - |
Trypanosoma cruzi | |
NADP+ | - |
Plasmodium falciparum |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00001 | - |
4-phospho-D-erythronohydroxamic acid | pH 7.5, 20°C | Trypanosoma brucei | |
0.000035 | - |
phosphoric acid mono-[(5R,4R)-5-hydroxycarbamoyl-2,2-dimethyl[1,3]dioxolan-4-ylmethyl] ester | pH 7.5, 20°C | Trypanosoma brucei | |
0.00008 | - |
acetic acid (2R,1R)-2-acetoxy-1-hydroxycarbamoyl-3-phosphonooxypropyl ester | pH 7.5, 20°C | Trypanosoma brucei | |
0.00013 | - |
4-phospho-D-erythronate | pH 7.5, 20°C | Trypanosoma brucei | |
0.00036 | - |
acetic acid (2R,1R)-2-acetoxy-1-hydroxycarbamoyl-3-phosphonooxypropyl ester | pH 7.5, 20°C | Ovis aries | |
0.0011 | - |
phosphoric acid mono-[(5R,4R)-5-hydroxycarbamoyl-2,2-dimethyl[1,3]dioxolan-4-ylmethyl] ester | pH 7.5, 20°C | Ovis aries | |
0.0015 | - |
4-phopho-D-erythronamide | pH 7.5, 20°C | Trypanosoma brucei | |
0.0025 | - |
4-phospho-D-erythronohydroxamic acid | pH 7.5, 20°C | Ovis aries | |
0.0044 | - |
2-deoxy-6-phosphono-D-gluconate | pH 7.5, 20°C | Trypanosoma brucei | |
0.011 | - |
4-phospho-D-erythronate | pH 7.5, 20°C | Ovis aries | |
0.039 | - |
4-phospho-D-erythronamide | pH 7.5, 20°C | Ovis aries | |
0.04 | - |
[(2R)-2-acetoxy-3-phosphonooxypropane-1-sulfinyl]acetic acid | pH 7.5, 20°C | Trypanosoma brucei | |
0.109 | - |
acetic acid (1R,2R)-2-acetoxy-1-(acetylbenzyloxyaminocarbonyl)-3-(bis(benzyloxy)phosphoryloxy)propyl ester | pH 7.5, 20°C | Trypanosoma brucei | |
0.192 | - |
acetic acid (1R,2R)-2-acetoxy-1-(acetylbenzyloxyaminocarbonyl)-3-(bis(benzyloxy)phosphoryloxy)propyl ester | pH 7.5, 20°C | Ovis aries | |
0.198 | - |
(2R)-(2-hydroxy-3-phosphonooxypropane-1-sulfinyl)acetic acid | pH 7.5, 20°C | Trypanosoma brucei | |
0.588 | - |
phosphoric acid mono-[(4R,5R)-5-carbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl] ester | pH 7.5, 20°C | Trypanosoma brucei | |
0.625 | - |
[(2R)-2-acetoxy-3-phosphonooxypropane-1-sulfinyl]acetic acid | pH 7.5, 20°C | Ovis aries | |
0.714 | - |
phosphoric acid mono-[(4R,5R)-5-carbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl] ester | pH 7.5, 20°C | Ovis aries | |
0.77 | - |
2-deoxy-6-phosphono-D-gluconate | pH 7.5, 20°C | Ovis aries | |
0.784 | - |
(2R)-(2-hydroxy-3-phosphonooxypropane-1-sulfinyl)acetic acid | pH 7.5, 20°C | Ovis aries |