Activating Compound | Comment | Organism | Structure |
---|---|---|---|
AMP | 1 mM, relative activity 105% | Phormidium sp. |
General Stability | Organism |
---|---|
stable in 1 mM urea | Phormidium sp. |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5,5'-dithiobis(2-nitrobenzoic acid) | - |
Cyberlindnera jadinii | |
5,5'-dithiobis(2-nitrobenzoic acid) | - |
Enterococcus faecalis | |
5,5'-dithiobis(2-nitrobenzoic acid) | - |
Escherichia coli | |
5,5'-dithiobis(2-nitrobenzoic acid) | - |
Geobacillus stearothermophilus | |
5,5'-dithiobis(2-nitrobenzoic acid) | - |
Phormidium sp. | |
ADP | - |
Phormidium sp. | |
ADP | - |
Rattus norvegicus | |
ATP | - |
Escherichia coli | |
ATP | - |
Phormidium sp. | |
Cd2+ | - |
Enterococcus faecalis | |
Cd2+ | - |
Phormidium sp. | |
Cu2+ | - |
Enterococcus faecalis | |
Cu2+ | - |
Phormidium sp. | |
D-fructose 1,6-diphosphate | - |
Enterococcus faecalis | |
D-fructose 1,6-diphosphate | - |
Escherichia coli | |
D-fructose 1,6-diphosphate | - |
Neurospora crassa | |
D-fructose 1,6-diphosphate | - |
Phormidium sp. | |
D-fructose 6-phosphate | - |
Phormidium sp. | |
D-ribulose 5-phosphate | - |
Cyberlindnera jadinii | |
D-ribulose 5-phosphate | - |
Phormidium sp. | |
Hg2+ | - |
Geobacillus stearothermophilus | |
Hg2+ | HgCl2 | Phormidium sp. | |
N-ethylmaleimide | - |
Phormidium sp. | |
NADPH | - |
Escherichia coli | |
NADPH | - |
Geobacillus stearothermophilus | |
NADPH | - |
Neurospora crassa | |
NADPH | - |
Phormidium sp. | |
NADPH | - |
Rattus norvegicus | |
p-chloromercuribenzoate | - |
Enterococcus faecalis | |
p-chloromercuribenzoate | - |
Escherichia coli | |
p-chloromercuribenzoate | - |
Geobacillus stearothermophilus | |
p-chloromercuribenzoate | - |
Phormidium sp. | |
Rose bengal | - |
Escherichia coli | |
Rose bengal | - |
Geobacillus stearothermophilus | |
Rose bengal | - |
Neurospora crassa | |
Rose bengal | - |
Phormidium sp. | |
Zn2+ | - |
Enterococcus faecalis | |
Zn2+ | - |
Phormidium sp. |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.01 | - |
NADP+ | - |
Synechococcus sp. | |
0.013 | - |
NADP+ | - |
Phormidium sp. | |
0.025 | - |
NADP+ | - |
Synechococcus sp. | |
0.036 | - |
6-phosphogluconate | - |
Phormidium sp. | |
0.04 | - |
6-phosphogluconate | - |
Synechococcus sp. | |
0.09 | - |
6-phosphogluconate | - |
Synechococcus sp. |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | activated by 1 mM CaCl2, relative activity 146.6% | Phormidium sp. | |
Mg2+ | requires Mg2+ for full activity | Cyberlindnera jadinii | |
Mg2+ | requires Mg2+ for full activity | Geobacillus stearothermophilus | |
Mn2+ | activated by 1 mM MnCl2, relative activity 142.1% | Phormidium sp. |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
52000 | - |
2 * 52000, SDS-PAGE | Phormidium sp. |
100000 | - |
- |
Cyberlindnera jadinii |
100000 | - |
- |
Escherichia coli |
100000 | - |
- |
Geobacillus stearothermophilus |
104000 | - |
gel filtration | Phormidium sp. |
108000 | - |
- |
Enterococcus faecalis |
110000 | - |
- |
Neurospora crassa |
112000 | - |
- |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
6-phospho-D-gluconate + NADP+ | Cyberlindnera jadinii | - |
D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
r | |
6-phospho-D-gluconate + NADP+ | Enterococcus faecalis | - |
D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
r | |
6-phospho-D-gluconate + NADP+ | Escherichia coli | enzyme specific for the oxidative pentose phosphate pathway | D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
r | |
6-phospho-D-gluconate + NADP+ | Rattus norvegicus | enzyme specific for the oxidative pentose phosphate pathway | D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
r | |
6-phospho-D-gluconate + NADP+ | Geobacillus stearothermophilus | enzyme specific for the oxidative pentose phosphate pathway | D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
r | |
6-phospho-D-gluconate + NADP+ | Neurospora crassa | enzyme specific for the oxidative pentose phosphate pathway | D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
r | |
6-phospho-D-gluconate + NADP+ | Synechococcus sp. | enzyme specific for the oxidative pentose phosphate pathway | D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
r | |
6-phospho-D-gluconate + NADP+ | Phormidium sp. | enzyme specific for the oxidative pentose phosphate pathway | D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
r | |
6-phospho-D-gluconate + NADP+ | Synechococcus sp. PCC 6307 | enzyme specific for the oxidative pentose phosphate pathway | D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
r | |
6-phospho-D-gluconate + NADP+ | Synechococcus sp. PCC 6716 | enzyme specific for the oxidative pentose phosphate pathway | D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cyberlindnera jadinii | - |
- |
- |
Enterococcus faecalis | - |
- |
- |
Escherichia coli | - |
- |
- |
Geobacillus stearothermophilus | - |
- |
- |
Neurospora crassa | - |
- |
- |
Phormidium sp. | - |
filamentous cyanobacterium | - |
Rattus norvegicus | - |
rat | - |
Synechococcus sp. | - |
- |
- |
Synechococcus sp. PCC 6307 | - |
- |
- |
Synechococcus sp. PCC 6716 | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Phormidium sp. |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
38 | - |
- |
Phormidium sp. |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
6-phospho-D-gluconate + NADP+ | - |
Cyberlindnera jadinii | D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
r | |
6-phospho-D-gluconate + NADP+ | - |
Escherichia coli | D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
r | |
6-phospho-D-gluconate + NADP+ | - |
Rattus norvegicus | D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
r | |
6-phospho-D-gluconate + NADP+ | - |
Geobacillus stearothermophilus | D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
r | |
6-phospho-D-gluconate + NADP+ | - |
Neurospora crassa | D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
r | |
6-phospho-D-gluconate + NADP+ | - |
Enterococcus faecalis | D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
r | |
6-phospho-D-gluconate + NADP+ | - |
Synechococcus sp. | D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
r | |
6-phospho-D-gluconate + NADP+ | - |
Phormidium sp. | D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
r | |
6-phospho-D-gluconate + NADP+ | enzyme specific for the oxidative pentose phosphate pathway | Escherichia coli | D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
r | |
6-phospho-D-gluconate + NADP+ | enzyme specific for the oxidative pentose phosphate pathway | Rattus norvegicus | D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
r | |
6-phospho-D-gluconate + NADP+ | enzyme specific for the oxidative pentose phosphate pathway | Geobacillus stearothermophilus | D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
r | |
6-phospho-D-gluconate + NADP+ | enzyme specific for the oxidative pentose phosphate pathway | Neurospora crassa | D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
r | |
6-phospho-D-gluconate + NADP+ | enzyme specific for the oxidative pentose phosphate pathway | Synechococcus sp. | D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
r | |
6-phospho-D-gluconate + NADP+ | enzyme specific for the oxidative pentose phosphate pathway | Phormidium sp. | D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
r | |
6-phospho-D-gluconate + NADP+ | - |
Synechococcus sp. PCC 6307 | D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
r | |
6-phospho-D-gluconate + NADP+ | enzyme specific for the oxidative pentose phosphate pathway | Synechococcus sp. PCC 6307 | D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
r | |
6-phospho-D-gluconate + NADP+ | - |
Synechococcus sp. PCC 6716 | D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
r | |
6-phospho-D-gluconate + NADP+ | enzyme specific for the oxidative pentose phosphate pathway | Synechococcus sp. PCC 6716 | D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
r |
Subunits | Comment | Organism |
---|---|---|
dimer | - |
Cyberlindnera jadinii |
dimer | - |
Escherichia coli |
dimer | - |
Rattus norvegicus |
dimer | - |
Geobacillus stearothermophilus |
dimer | - |
Neurospora crassa |
dimer | - |
Enterococcus faecalis |
dimer | 2 * 52000, SDS-PAGE | Phormidium sp. |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
40 | - |
- |
Phormidium sp. |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
50 | - |
- |
Escherichia coli |
50 | - |
- |
Neurospora crassa |
50 | - |
stable below, retains 50% original activity at 57°C | Phormidium sp. |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | 8 | - |
Geobacillus stearothermophilus |
7.5 | 8 | - |
Enterococcus faecalis |
8 | - |
- |
Cyberlindnera jadinii |
8 | - |
- |
Rattus norvegicus |
8 | - |
- |
Geobacillus stearothermophilus |
8 | - |
- |
Phormidium sp. |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
4 | 9.6 | - |
Phormidium sp. |
pH Stability | pH Stability Maximum | Comment | Organism |
---|---|---|---|
6 | 9 | - |
Phormidium sp. |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Cyberlindnera jadinii | |
NADP+ | - |
Escherichia coli | |
NADP+ | - |
Rattus norvegicus | |
NADP+ | - |
Geobacillus stearothermophilus | |
NADP+ | - |
Neurospora crassa | |
NADP+ | - |
Enterococcus faecalis | |
NADP+ | no activity observed when NAD+ is substituted for NADP+ | Phormidium sp. |