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Literature summary for 1.1.1.44 extracted from

  • Sawa, Y.; Suzuki, K.; Ochiai, H.
    Purification and characterization of 6-phosphogluconate dehydrogenase from Phormidium sp. (1985), Agric. Biol. Chem., 49, 2543-2549.
No PubMed abstract available

Activating Compound

Activating Compound Comment Organism Structure
AMP 1 mM, relative activity 105% Phormidium sp.

General Stability

General Stability Organism
stable in 1 mM urea Phormidium sp.

Inhibitors

Inhibitors Comment Organism Structure
5,5'-dithiobis(2-nitrobenzoic acid)
-
Cyberlindnera jadinii
5,5'-dithiobis(2-nitrobenzoic acid)
-
Enterococcus faecalis
5,5'-dithiobis(2-nitrobenzoic acid)
-
Escherichia coli
5,5'-dithiobis(2-nitrobenzoic acid)
-
Geobacillus stearothermophilus
5,5'-dithiobis(2-nitrobenzoic acid)
-
Phormidium sp.
ADP
-
Phormidium sp.
ADP
-
Rattus norvegicus
ATP
-
Escherichia coli
ATP
-
Phormidium sp.
Cd2+
-
Enterococcus faecalis
Cd2+
-
Phormidium sp.
Cu2+
-
Enterococcus faecalis
Cu2+
-
Phormidium sp.
D-fructose 1,6-diphosphate
-
Enterococcus faecalis
D-fructose 1,6-diphosphate
-
Escherichia coli
D-fructose 1,6-diphosphate
-
Neurospora crassa
D-fructose 1,6-diphosphate
-
Phormidium sp.
D-fructose 6-phosphate
-
Phormidium sp.
D-ribulose 5-phosphate
-
Cyberlindnera jadinii
D-ribulose 5-phosphate
-
Phormidium sp.
Hg2+
-
Geobacillus stearothermophilus
Hg2+ HgCl2 Phormidium sp.
N-ethylmaleimide
-
Phormidium sp.
NADPH
-
Escherichia coli
NADPH
-
Geobacillus stearothermophilus
NADPH
-
Neurospora crassa
NADPH
-
Phormidium sp.
NADPH
-
Rattus norvegicus
p-chloromercuribenzoate
-
Enterococcus faecalis
p-chloromercuribenzoate
-
Escherichia coli
p-chloromercuribenzoate
-
Geobacillus stearothermophilus
p-chloromercuribenzoate
-
Phormidium sp.
Rose bengal
-
Escherichia coli
Rose bengal
-
Geobacillus stearothermophilus
Rose bengal
-
Neurospora crassa
Rose bengal
-
Phormidium sp.
Zn2+
-
Enterococcus faecalis
Zn2+
-
Phormidium sp.

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.01
-
NADP+
-
Synechococcus sp.
0.013
-
NADP+
-
Phormidium sp.
0.025
-
NADP+
-
Synechococcus sp.
0.036
-
6-phosphogluconate
-
Phormidium sp.
0.04
-
6-phosphogluconate
-
Synechococcus sp.
0.09
-
6-phosphogluconate
-
Synechococcus sp.

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ activated by 1 mM CaCl2, relative activity 146.6% Phormidium sp.
Mg2+ requires Mg2+ for full activity Cyberlindnera jadinii
Mg2+ requires Mg2+ for full activity Geobacillus stearothermophilus
Mn2+ activated by 1 mM MnCl2, relative activity 142.1% Phormidium sp.

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
52000
-
2 * 52000, SDS-PAGE Phormidium sp.
100000
-
-
Cyberlindnera jadinii
100000
-
-
Escherichia coli
100000
-
-
Geobacillus stearothermophilus
104000
-
gel filtration Phormidium sp.
108000
-
-
Enterococcus faecalis
110000
-
-
Neurospora crassa
112000
-
-
Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6-phospho-D-gluconate + NADP+ Cyberlindnera jadinii
-
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
r
6-phospho-D-gluconate + NADP+ Enterococcus faecalis
-
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
r
6-phospho-D-gluconate + NADP+ Escherichia coli enzyme specific for the oxidative pentose phosphate pathway D-ribulose 5-phosphate + CO2 + NADPH + H+
-
r
6-phospho-D-gluconate + NADP+ Rattus norvegicus enzyme specific for the oxidative pentose phosphate pathway D-ribulose 5-phosphate + CO2 + NADPH + H+
-
r
6-phospho-D-gluconate + NADP+ Geobacillus stearothermophilus enzyme specific for the oxidative pentose phosphate pathway D-ribulose 5-phosphate + CO2 + NADPH + H+
-
r
6-phospho-D-gluconate + NADP+ Neurospora crassa enzyme specific for the oxidative pentose phosphate pathway D-ribulose 5-phosphate + CO2 + NADPH + H+
-
r
6-phospho-D-gluconate + NADP+ Synechococcus sp. enzyme specific for the oxidative pentose phosphate pathway D-ribulose 5-phosphate + CO2 + NADPH + H+
-
r
6-phospho-D-gluconate + NADP+ Phormidium sp. enzyme specific for the oxidative pentose phosphate pathway D-ribulose 5-phosphate + CO2 + NADPH + H+
-
r
6-phospho-D-gluconate + NADP+ Synechococcus sp. PCC 6307 enzyme specific for the oxidative pentose phosphate pathway D-ribulose 5-phosphate + CO2 + NADPH + H+
-
r
6-phospho-D-gluconate + NADP+ Synechococcus sp. PCC 6716 enzyme specific for the oxidative pentose phosphate pathway D-ribulose 5-phosphate + CO2 + NADPH + H+
-
r

Organism

Organism UniProt Comment Textmining
Cyberlindnera jadinii
-
-
-
Enterococcus faecalis
-
-
-
Escherichia coli
-
-
-
Geobacillus stearothermophilus
-
-
-
Neurospora crassa
-
-
-
Phormidium sp.
-
filamentous cyanobacterium
-
Rattus norvegicus
-
rat
-
Synechococcus sp.
-
-
-
Synechococcus sp. PCC 6307
-
-
-
Synechococcus sp. PCC 6716
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Phormidium sp.

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
38
-
-
Phormidium sp.

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6-phospho-D-gluconate + NADP+
-
Cyberlindnera jadinii D-ribulose 5-phosphate + CO2 + NADPH + H+
-
r
6-phospho-D-gluconate + NADP+
-
Escherichia coli D-ribulose 5-phosphate + CO2 + NADPH + H+
-
r
6-phospho-D-gluconate + NADP+
-
Rattus norvegicus D-ribulose 5-phosphate + CO2 + NADPH + H+
-
r
6-phospho-D-gluconate + NADP+
-
Geobacillus stearothermophilus D-ribulose 5-phosphate + CO2 + NADPH + H+
-
r
6-phospho-D-gluconate + NADP+
-
Neurospora crassa D-ribulose 5-phosphate + CO2 + NADPH + H+
-
r
6-phospho-D-gluconate + NADP+
-
Enterococcus faecalis D-ribulose 5-phosphate + CO2 + NADPH + H+
-
r
6-phospho-D-gluconate + NADP+
-
Synechococcus sp. D-ribulose 5-phosphate + CO2 + NADPH + H+
-
r
6-phospho-D-gluconate + NADP+
-
Phormidium sp. D-ribulose 5-phosphate + CO2 + NADPH + H+
-
r
6-phospho-D-gluconate + NADP+ enzyme specific for the oxidative pentose phosphate pathway Escherichia coli D-ribulose 5-phosphate + CO2 + NADPH + H+
-
r
6-phospho-D-gluconate + NADP+ enzyme specific for the oxidative pentose phosphate pathway Rattus norvegicus D-ribulose 5-phosphate + CO2 + NADPH + H+
-
r
6-phospho-D-gluconate + NADP+ enzyme specific for the oxidative pentose phosphate pathway Geobacillus stearothermophilus D-ribulose 5-phosphate + CO2 + NADPH + H+
-
r
6-phospho-D-gluconate + NADP+ enzyme specific for the oxidative pentose phosphate pathway Neurospora crassa D-ribulose 5-phosphate + CO2 + NADPH + H+
-
r
6-phospho-D-gluconate + NADP+ enzyme specific for the oxidative pentose phosphate pathway Synechococcus sp. D-ribulose 5-phosphate + CO2 + NADPH + H+
-
r
6-phospho-D-gluconate + NADP+ enzyme specific for the oxidative pentose phosphate pathway Phormidium sp. D-ribulose 5-phosphate + CO2 + NADPH + H+
-
r
6-phospho-D-gluconate + NADP+
-
Synechococcus sp. PCC 6307 D-ribulose 5-phosphate + CO2 + NADPH + H+
-
r
6-phospho-D-gluconate + NADP+ enzyme specific for the oxidative pentose phosphate pathway Synechococcus sp. PCC 6307 D-ribulose 5-phosphate + CO2 + NADPH + H+
-
r
6-phospho-D-gluconate + NADP+
-
Synechococcus sp. PCC 6716 D-ribulose 5-phosphate + CO2 + NADPH + H+
-
r
6-phospho-D-gluconate + NADP+ enzyme specific for the oxidative pentose phosphate pathway Synechococcus sp. PCC 6716 D-ribulose 5-phosphate + CO2 + NADPH + H+
-
r

Subunits

Subunits Comment Organism
dimer
-
Cyberlindnera jadinii
dimer
-
Escherichia coli
dimer
-
Rattus norvegicus
dimer
-
Geobacillus stearothermophilus
dimer
-
Neurospora crassa
dimer
-
Enterococcus faecalis
dimer 2 * 52000, SDS-PAGE Phormidium sp.

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
40
-
-
Phormidium sp.

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
50
-
-
Escherichia coli
50
-
-
Neurospora crassa
50
-
stable below, retains 50% original activity at 57°C Phormidium sp.

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5 8
-
Geobacillus stearothermophilus
7.5 8
-
Enterococcus faecalis
8
-
-
Cyberlindnera jadinii
8
-
-
Rattus norvegicus
8
-
-
Geobacillus stearothermophilus
8
-
-
Phormidium sp.

pH Range

pH Minimum pH Maximum Comment Organism
4 9.6
-
Phormidium sp.

pH Stability

pH Stability pH Stability Maximum Comment Organism
6 9
-
Phormidium sp.

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Cyberlindnera jadinii
NADP+
-
Escherichia coli
NADP+
-
Rattus norvegicus
NADP+
-
Geobacillus stearothermophilus
NADP+
-
Neurospora crassa
NADP+
-
Enterococcus faecalis
NADP+ no activity observed when NAD+ is substituted for NADP+ Phormidium sp.