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Literature summary for 1.1.1.44 extracted from

  • Dyson, J.E.D.; D'Orazio, R.E.; Hanson, W.H.
    Sheep liver 6-phosphogluconate dehydrogenase: Isolation procedure and effect of pH, ionic strength, and metal ions on the kinetic parameters (1973), Arch. Biochem. Biophys., 154, 623-635.
    View publication on PubMed
Search for more literature for 1.1.1.44

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00571
-
 NADP+ 10 mM Tris-acetate, 10 mM MgCl2, pH 7.7 Ovis aries
0.00631
-
 NADP+ 10 mM Tris-acetate, 80 mM KCl, pH 7.7 Ovis aries
0.00676
-
 NADP+ 50 mM Tris-acetate, pH 7.7 Ovis aries
0.00861
-
 NADP+ 50 mM Tris-acetate, 20 mM MgCl2, pH 7.7 Ovis aries
0.00893
-
 NADP+ 10 mM Tris-acetate, pH 7.7 Ovis aries
0.0149
-
 6-phosphogluconate 50 mM Tris-acetate, 5-10 mM MgCl2, pH 7.7 Ovis aries
0.015
-
 6-phosphogluconate
-
 Ovis aries
0.016
-
 NADP+
-
 Ovis aries
0.0161
-
 6-phosphogluconate 50 mM Tris-acetate, pH 7.7 Ovis aries
0.0167
-
 6-phosphogluconate 10 mM Tris-acetate, 80 mM KCl, pH 7.7 Ovis aries
0.0413
-
 6-phosphogluconate 10 mM Tris-acetate, pH 7.7 Ovis aries
0.05
-
 6-phosphogluconate 50 mM Tris-acetate, 20 mM MgCl2, KCl, pH 7.7 Ovis aries

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6-phospho-D-gluconate + NADP+ Cyberlindnera jadinii
-
 D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
6-phospho-D-gluconate + NADP+ Rattus norvegicus enzyme specific for the oxidative pentose phosphate pathway D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
6-phospho-D-gluconate + NADP+ Ovis aries enzyme specific for the oxidative pentose phosphate pathway D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r

Organism

Organism UniProt Comment Textmining
Cyberlindnera jadinii
-
-
-
Ovis aries
-
 sheep
-
Rattus norvegicus
-
 rat
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-
liver
-
 Ovis aries
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
17.4
-
-
 Ovis aries

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6-phospho-D-gluconate + NADP+
-
 Cyberlindnera jadinii D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
6-phospho-D-gluconate + NADP+
-
 Rattus norvegicus D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
6-phospho-D-gluconate + NADP+
-
 Ovis aries D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
6-phospho-D-gluconate + NADP+ enzyme specific for the oxidative pentose phosphate pathway Rattus norvegicus D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
6-phospho-D-gluconate + NADP+ enzyme specific for the oxidative pentose phosphate pathway Ovis aries D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.7
-
 low substrate concentrations Ovis aries
9.1
-
-
 Ovis aries

pH Range

pH Minimum pH Maximum Comment Organism
5.5 9
-
 Ovis aries

pH Stability

pH Stability pH Stability Maximum Comment Organism
9.1
-
 unstable at higher pH values Ovis aries