Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-[(1R,2S)-1-hydroxy-2-{[2-(4-hydroxyphenyl)ethyl]amino}propyl]phenol | non-competitive inhibition | Homo sapiens | |
dacarbazine | non-competitive inhibition | Homo sapiens | |
Furosemide | non-competitive inhibition | Homo sapiens | |
gadopentetic acid | non-competitive inhibition | Homo sapiens | |
ketotifen | non-competitive inhibition | Homo sapiens | |
meloxicam | non-competitive inhibition | Homo sapiens | |
methotrexate | non-competitive inhibition | Homo sapiens | |
metochloropramide | non-competitive inhibition | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
purified 2256times in a yield of 44.22% by using ammonium sulfate precipitation and 2', 5'-ADP Sepharose 4B affinity gel. Temperature of +4°C is maintained during the purification process | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
6-phospho-D-gluconate + NADP+ | - |
Homo sapiens | 6-phospho-2-dehydro-D-gluconate + NADPH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
6PGDH | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.002 | - |
metochloropramide | 25°C, pH 8.0, non-competitive inhibition | Homo sapiens | |
0.006 | - |
4-[(1R,2S)-1-hydroxy-2-{[2-(4-hydroxyphenyl)ethyl]amino}propyl]phenol | 25°C, pH 8.0, non-competitive inhibition | Homo sapiens | |
0.008 | - |
ketotifen | 25°C, pH 8.0, non-competitive inhibition | Homo sapiens | |
0.01 | - |
dacarbazine | 25°C, pH 8.0, non-competitive inhibition | Homo sapiens | |
0.05 | - |
meloxicam | 25°C, pH 8.0, non-competitive inhibition | Homo sapiens | |
0.0734 | - |
gadopentetic acid | 25°C, pH 8.0, non-competitive inhibition | Homo sapiens | |
0.127 | - |
Furosemide | 25°C, pH 8.0, non-competitive inhibition | Homo sapiens | |
0.136 | - |
methotrexate | 25°C, pH 8.0, non-competitive inhibition | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.008 | - |
25°C, pH 8.0, non-competitive inhibition | Homo sapiens | ketotifen | |
0.01 | - |
25°C, pH 8.0, non-competitive inhibition | Homo sapiens | dacarbazine | |
0.05 | - |
25°C, pH 8.0, non-competitive inhibition | Homo sapiens | meloxicam | |
0.125 | - |
25°C, pH 8.0, non-competitive inhibition | Homo sapiens | Furosemide | |
0.142 | - |
25°C, pH 8.0, non-competitive inhibition | Homo sapiens | methotrexate | |
3.27 | - |
25°C, pH 8.0, non-competitive inhibition | Homo sapiens | metochloropramide | |
3.66 | - |
25°C, pH 8.0, non-competitive inhibition | Homo sapiens | 4-[(1R,2S)-1-hydroxy-2-{[2-(4-hydroxyphenyl)ethyl]amino}propyl]phenol | |
209 | - |
25°C, pH 8.0, non-competitive inhibition | Homo sapiens | gadopentetic acid |