Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.42 extracted from

  • Contreras-Shannon, V.; McAlister-Henn, L.
    Influence of compartmental localization on the function of yeast NADP+-specific isocitrate dehydrogenases (2004), Arch. Biochem. Biophys., 423, 235-246.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information isozyme IDP3 is inducible by fatty acids, isozyme IDP2 by non-fermentable carbon sources, expression of isozyme IDP1 is constitutive Saccharomyces cerevisiae

Cloned(Commentary)

Cloned (Comment) Organism
exchange of promotors and altering of organellar targeting for expression of isozymes IDO2 and IDO3 in mitochondria, and of isozymes IDP1 and IDP3 in the cytosol, functional complementation studies using mutant strains Saccharomyces cerevisiae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.01
-
NADPH isozyme IDP1 Saccharomyces cerevisiae
0.02
-
NADP+ isozyme IDP2 and IDP3 Saccharomyces cerevisiae
0.03
-
NADP+ isozyme IDP1 Saccharomyces cerevisiae
0.03
-
isocitrate isozyme IDP1 Saccharomyces cerevisiae
0.04
-
NADPH isozyme IDP2 Saccharomyces cerevisiae
0.05
-
isocitrate isozyme IDP3 Saccharomyces cerevisiae
0.2
-
2-oxoglutarate isozyme IDP2 Saccharomyces cerevisiae
0.22
-
isocitrate isozyme IDP2 Saccharomyces cerevisiae
1.92
-
2-oxoglutarate isozyme IDP1 Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol isoyzme IDP2 Saccharomyces cerevisiae 5829
-
mitochondrion isozyme IDP1 Saccharomyces cerevisiae 5739
-
additional information influence of subcellular localization on isozyme activities, overview Saccharomyces cerevisiae
-
-
peroxisome isozyme IDP3 Saccharomyces cerevisiae 5777
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
isocitrate + NADP+ Saccharomyces cerevisiae isozymes are compartment interchangeable for glutamate synthesis, although mitochondrial localization has a positive impact on this function during fermentative growth 2-oxoglutarate + CO2 + NADPH + H+
-
?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
3 isozymes: mitochondrial IDP1, cytosolic IDP2, peroxisomal IDP3
-

Oxidation Stability

Oxidation Stability Organism
isozyme IDP3 shows highest defense against endogeneous oxidative stress Saccharomyces cerevisiae

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
wild-type and diverse mutant strains Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
isocitrate + NADP+ isozymes are compartment interchangeable for glutamate synthesis, although mitochondrial localization has a positive impact on this function during fermentative growth Saccharomyces cerevisiae 2-oxoglutarate + CO2 + NADPH + H+
-
?
isocitrate + NADP+ reaction is reversible for isozymes IDP1 and IDP2 Saccharomyces cerevisiae 2-oxoglutarate + CO2 + NADPH + H+
-
r

Synonyms

Synonyms Comment Organism
NADP+-specific isocitrate dehydrogenase
-
Saccharomyces cerevisiae

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.8
-
assay at Saccharomyces cerevisiae

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Saccharomyces cerevisiae
NADPH
-
Saccharomyces cerevisiae