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Literature summary for 1.1.1.42 extracted from
- A multilocus system for studying tissue and subcellular specialization. The three NADP-dependent isocitrate dehydrogenase isozymes of the fish Fundulus heteroclitus (1985), J. Biol. Chem., 260, 9106-9113.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Fundulus heteroclitus | 5737 | - |
| mitochondrion | - |
Fundulus heteroclitus | 5739 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | absolute requirement for divalent cations | Fundulus heteroclitus |  |
| Mn2+ | absolute requirement for divalent cations | Fundulus heteroclitus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 90000 | - |
gel filtration, 3 isoenzymes | Fundulus heteroclitus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| isocitrate + NADP+ | Fundulus heteroclitus | - |
2-oxoglutarate + NADPH + H+ + CO2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Fundulus heteroclitus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Fundulus heteroclitus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Fundulus heteroclitus | - |
| intestine | - |
Fundulus heteroclitus | - |
| liver | - |
Fundulus heteroclitus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| isocitrate + NADP+ | - |
Fundulus heteroclitus | 2-oxoglutarate + NADPH + H+ + CO2 | - |
? | |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 35 | - |
isoenzyme C, half-life 20 min | Fundulus heteroclitus |
| 49 | - |
isoenzyme A, half-life 20 min | Fundulus heteroclitus |
| 52 | - |
isoenzyme C, half-life 20 min, presence of isocitrate | Fundulus heteroclitus |
| 54 | - |
isoenzyme B, T50-value | Fundulus heteroclitus |
| 58 | - |
isoenzyme A, T50-value, presence of isocitrate | Fundulus heteroclitus |
| 69 | - |
isoenzyme B, T50-value, presence of isocitrate | Fundulus heteroclitus |
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Release 2023.1 (January 2023)
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