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Literature summary for 1.1.1.41 extracted from

  • Anderson, S.L.; Lin, A.P.; McAlister-Henn, L.
    Analysis of interactions with mitochondrial mRNA using mutant forms of yeast NAD(+)-specific isocitrate dehydrogenase (2005), Biochemistry, 44, 16776-16784.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.1.1.41

Activating Compound

Activating Compound Comment Organism Structure
NAD+
-
 Saccharomyces cerevisiae

Protein Variants

Protein Variants Comment Organism
K171L mutant IDH1K171L Saccharomyces cerevisiae

Inhibitors

Inhibitors Comment Organism Structure
130-nucleotide transcript containing the 5'-untranslated regions of the yeast mitochondrial COX2 mRNA inhibition with a 50% reduction in activity observed with 40 nM mRNA Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Saccharomyces cerevisiae 5739
-

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-
Saccharomyces cerevisiae MMY011
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni2+-nitrilotriacetic acid superflow resin chromatography Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-isocitrate + NAD+
-
 Saccharomyces cerevisiae 2-oxoglutarate + CO2 + NADH
-
 ir
D-isocitrate + NAD+
-
 Saccharomyces cerevisiae MMY011 2-oxoglutarate + CO2 + NADH
-
 ir

Synonyms

Synonyms Comment Organism
IDH
-
 Saccharomyces cerevisiae
NAD+-specific isocitrate dehydrogenase
-
 Saccharomyces cerevisiae

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Saccharomyces cerevisiae