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Literature summary for 1.1.1.41 extracted from

  • Plaut, G.W.E.
    Isocitrate dehydrogenase (1963), The Enzymes, 2nd Ed. (Boyer, P. D. , Lardy, H. , Myrbäck, K. , eds. ), 7, 105-126.
No PubMed abstract available

Activating Compound

Activating Compound Comment Organism Structure
AMP
-
Saccharomyces cerevisiae

Inhibitors

Inhibitors Comment Organism Structure
ATP
-
Bos taurus
CN-
-
Bos taurus
CN-
-
Pisum sativum
CN-
-
Saccharomyces cerevisiae
molybdate
-
Bos taurus
molybdate
-
Saccharomyces cerevisiae
N3-
-
Bos taurus
N3-
-
Saccharomyces cerevisiae
p-hydroxymercuribenzoate
-
Bos taurus
thiocyanate
-
Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.11
-
D,L-isocitrate
-
Saccharomyces cerevisiae
0.45
-
D,L-isocitrate
-
Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Cavia porcellus 5739
-
mitochondrion
-
Homo sapiens 5739
-
mitochondrion
-
Rattus norvegicus 5739
-
mitochondrion
-
Saccharomyces cerevisiae 5739
-
mitochondrion
-
Bos taurus 5739
-
mitochondrion
-
Aspergillus niger 5739
-
mitochondrion
-
Pisum sativum 5739
-
mitochondrion
-
Columba livia 5739
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Saccharomyces cerevisiae
Mg2+
-
Bos taurus
Mg2+
-
Aspergillus niger
Mg2+
-
Pisum sativum
Mn2+ requires divalent cations Saccharomyces cerevisiae
Mn2+ requires divalent cations Bos taurus
Mn2+ requires divalent cations Pisum sativum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
isocitrate + NAD+ Cavia porcellus
-
2-oxoglutarate + CO2 + NADH + H+
-
?
isocitrate + NAD+ Homo sapiens
-
2-oxoglutarate + CO2 + NADH + H+
-
?
isocitrate + NAD+ Rattus norvegicus
-
2-oxoglutarate + CO2 + NADH + H+
-
?
isocitrate + NAD+ Saccharomyces cerevisiae
-
2-oxoglutarate + CO2 + NADH + H+
-
?
isocitrate + NAD+ Bos taurus
-
2-oxoglutarate + CO2 + NADH + H+
-
?
isocitrate + NAD+ Aspergillus niger
-
2-oxoglutarate + CO2 + NADH + H+
-
?
isocitrate + NAD+ Pisum sativum
-
2-oxoglutarate + CO2 + NADH + H+
-
?
isocitrate + NAD+ Columba livia
-
2-oxoglutarate + CO2 + NADH + H+
-
?

Organism

Organism UniProt Comment Textmining
Aspergillus niger
-
-
-
Bos taurus
-
-
-
Cavia porcellus
-
-
-
Columba livia
-
pigeon
-
Homo sapiens
-
-
-
Pisum sativum
-
pea
-
Rattus norvegicus
-
-
-
Saccharomyces cerevisiae
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
Cavia porcellus
-
heart
-
Homo sapiens
-
heart
-
Rattus norvegicus
-
heart
-
Bos taurus
-
muscle
-
Homo sapiens
-
muscle breast muscle Columba livia
-
placenta
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
isocitrate + NAD+
-
Cavia porcellus 2-oxoglutarate + CO2 + NADH + H+
-
?
isocitrate + NAD+
-
Homo sapiens 2-oxoglutarate + CO2 + NADH + H+
-
?
isocitrate + NAD+
-
Rattus norvegicus 2-oxoglutarate + CO2 + NADH + H+
-
?
isocitrate + NAD+
-
Saccharomyces cerevisiae 2-oxoglutarate + CO2 + NADH + H+
-
?
isocitrate + NAD+
-
Bos taurus 2-oxoglutarate + CO2 + NADH + H+
-
?
isocitrate + NAD+
-
Aspergillus niger 2-oxoglutarate + CO2 + NADH + H+
-
?
isocitrate + NAD+
-
Pisum sativum 2-oxoglutarate + CO2 + NADH + H+
-
?
isocitrate + NAD+
-
Columba livia 2-oxoglutarate + CO2 + NADH + H+
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5
-
-
Bos taurus
7.5
-
-
Saccharomyces cerevisiae
7.5
-
-
Pisum sativum

pH Range

pH Minimum pH Maximum Comment Organism
6.5 8.5
-
Saccharomyces cerevisiae
6.5 8.5
-
Pisum sativum

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Cavia porcellus
NAD+
-
Homo sapiens
NAD+
-
Rattus norvegicus
NAD+
-
Saccharomyces cerevisiae
NAD+
-
Bos taurus
NAD+
-
Aspergillus niger
NAD+
-
Pisum sativum
NAD+
-
Columba livia